Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL

We assessed the genetic polymorphism of mannose-binding lectin (MBL) in 93 patients with chronic hepatitis C (45 responders and 48 nonresponders to interferon) and 218 healthy controls. Mutant allele was identified only at codon 54 (Gly→Asp), leading to three genotypes (54 m/m, 54 W/m, and 54 W/W)....

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Bibliographic Details
Published in:Archives of virology 1998-01, Vol.143 (4), p.645-651
Main Authors: Matsushita, M, Hijikata, M, Ohta, Y, Iwata, K, Matsumoto, M, Nakao, K, Kanai, K, Yoshida, N, Baba, K, Mishiro, S
Format: Article
Language:English
Subjects:
Adult
Alleles
Biological and medical sciences
Carrier Proteins - genetics
Case-Control Studies
chronic hepatitis C
Collectins
Gene Frequency
genes
genetic polymorphism
Genetic Predisposition to Disease
Genotype
Hepatitis
Hepatitis C virus
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Human viral diseases
Humans
Infectious diseases
Interferon
interferons
Interferons - therapeutic use
Japan
lectins
Medical sciences
mutants
Mutation
patients
Point Mutation
Viral diseases
Viral hepatitis
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Summary:We assessed the genetic polymorphism of mannose-binding lectin (MBL) in 93 patients with chronic hepatitis C (45 responders and 48 nonresponders to interferon) and 218 healthy controls. Mutant allele was identified only at codon 54 (Gly→Asp), leading to three genotypes (54 m/m, 54 W/m, and 54 W/W). Frequency of 54 m/m was significantly lower in interferon-responders (2.2%) compared to those in nonresponders (14.6%) and controls (10.6%): p
ISSN:0304-8608
1432-8798
DOI:10.1007/s007050050320