Coexisting primary early gastric plasmacytoma and sarcoidosis with hypercalcaemia

We report on a 61-year-old woman with coexisting early stage primary gastric plasmacytoma and sarcoidosis with hypercalcaemia. Laboratory data on admission showed hypercalcaemia, with 12.8 mg/dl, parathyroid hormone-related peptide (PTHrP) 1.2 pmol/l, C-PTHrP 69.5 pmol/l, and 1,25-dihydroxyvitamin D...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1998-05, Vol.432 (5), p.473-476
Main Authors: MORII, S, OKA, K, NAOI, Y, KOTSUJI, T, NIHEI, T, NAGAYAMA, R, KASHIMURA, K, KAMETA, S, YATABE, Y, MORI, N
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cholecalciferol - blood
Female
Hematologic and hematopoietic diseases
Humans
Hypercalcemia - blood
Hypercalcemia - complications
Hypercalcemia - pathology
Immunohistochemistry
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Neoplasm Proteins - metabolism
Parathyroid Hormone-Related Protein
Plasmacytoma - blood
Plasmacytoma - complications
Plasmacytoma - pathology
Proteins - metabolism
Sarcoidosis - blood
Sarcoidosis - complications
Sarcoidosis - pathology
Stomach Neoplasms - blood
Stomach Neoplasms - complications
Stomach Neoplasms - pathology
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Summary:We report on a 61-year-old woman with coexisting early stage primary gastric plasmacytoma and sarcoidosis with hypercalcaemia. Laboratory data on admission showed hypercalcaemia, with 12.8 mg/dl, parathyroid hormone-related peptide (PTHrP) 1.2 pmol/l, C-PTHrP 69.5 pmol/l, and 1,25-dihydroxyvitamin D3 46.7 pg/ml. Neoplastic plasma cells proliferated in the propria mucosa of the stomach, showed a monoclonal immunoglobulin of cytoplasmic IgA (lambda light chain) and were positive for leucocyte common antigen and epithelial membrane antigen on paraffin section prepared from a stomach biopsy specimen. Russel bodies were present, as were crystals. Abundant sarcoid granulomas were observed in many of the regional lymph nodes around the stomach and in the dermis of a skin nodule. The patient underwent subtotal gastrectomy with administration of antimyeloma chemotherapy. We suggest that the hypercalcaemia in this patient was due to PTHrP production by neoplastic plasma cells.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050194