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Competing causes of death for primary breast cancer
A patient's likelihood of dying from breast cancer or another cause can be assessed with competing risks analyses. Data for a cohort of 678 patients with primary invasive breast cancer accrued from 1971 to 1990, updated to 1995, included cause of death (e.g., breast cancer vs. other cause). We...
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| Published in: | Annals of surgical oncology 1998-06, Vol.5 (4), p.368-375 |
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| Main Authors: | , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c310t-df512daa647bbc04d83c79327d250f82fb59da3311316785e8a2c42bd8b1a4cc3 |
| container_end_page | 375 |
| container_issue | 4 |
| container_start_page | 368 |
| container_title | Annals of surgical oncology |
| container_volume | 5 |
| creator | Fish, E B Chapman, J A Link, M A |
| description | A patient's likelihood of dying from breast cancer or another cause can be assessed with competing risks analyses.
Data for a cohort of 678 patients with primary invasive breast cancer accrued from 1971 to 1990, updated to 1995, included cause of death (e.g., breast cancer vs. other cause). We investigated the effects of age, tumor size, nodal status, ER, PgR, and adjuvant therapy (hormones, chemotherapy, radiotherapy) on type of death and time to death for patients of all ages and for those over the age of 65 years.
Although there were no significant univariate differences in breast cancer death rates by age group (P=0.94), more patients over the age of 65 years died from other causes (41/207 [20%] of those older than 65 years vs. 16/471 [3%] of those younger than 65 years; P |
| doi_str_mv | 10.1007/BF02303502 |
| format | article |
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Data for a cohort of 678 patients with primary invasive breast cancer accrued from 1971 to 1990, updated to 1995, included cause of death (e.g., breast cancer vs. other cause). We investigated the effects of age, tumor size, nodal status, ER, PgR, and adjuvant therapy (hormones, chemotherapy, radiotherapy) on type of death and time to death for patients of all ages and for those over the age of 65 years.
Although there were no significant univariate differences in breast cancer death rates by age group (P=0.94), more patients over the age of 65 years died from other causes (41/207 [20%] of those older than 65 years vs. 16/471 [3%] of those younger than 65 years; P <.001). In competing risks analyses, older age was associated with non-breast cancer death, whereas larger tumor size was associated with breast cancer death. PgR was positively, and nodal status negatively, associated with survival, regardless of type. In the older patient group, the competing risks analyses identified similar effects for age and tumor size; in addition, higher ER assay values were less likely to be associated with breast cancer death.
With increased lifespan, there will be more breast cancer cases in women older than 65 years; we have shown that women in this group have more non-breast cancer deaths. It becomes important, then, to delineate differential effects of prognostic factors on competing causes of death.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1007/BF02303502</identifier><identifier>PMID: 9641460</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; Age ; Aged ; Breast cancer ; Breast Neoplasms - mortality ; Breast Neoplasms - therapy ; Cause of Death ; Chemotherapy ; Combined Modality Therapy ; Death ; Female ; Health risk assessment ; Humans ; Invasiveness ; Life span ; Mastectomy ; Medical prognosis ; Middle Aged ; Multivariate Analysis ; Patients ; Radiation therapy ; Regression Analysis ; Risk ; Survival Analysis</subject><ispartof>Annals of surgical oncology, 1998-06, Vol.5 (4), p.368-375</ispartof><rights>The Society of Surgical Oncology, Inc. 1998.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-df512daa647bbc04d83c79327d250f82fb59da3311316785e8a2c42bd8b1a4cc3</citedby><cites>FETCH-LOGICAL-c310t-df512daa647bbc04d83c79327d250f82fb59da3311316785e8a2c42bd8b1a4cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9641460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fish, E B</creatorcontrib><creatorcontrib>Chapman, J A</creatorcontrib><creatorcontrib>Link, M A</creatorcontrib><title>Competing causes of death for primary breast cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><description>A patient's likelihood of dying from breast cancer or another cause can be assessed with competing risks analyses.
Data for a cohort of 678 patients with primary invasive breast cancer accrued from 1971 to 1990, updated to 1995, included cause of death (e.g., breast cancer vs. other cause). We investigated the effects of age, tumor size, nodal status, ER, PgR, and adjuvant therapy (hormones, chemotherapy, radiotherapy) on type of death and time to death for patients of all ages and for those over the age of 65 years.
Although there were no significant univariate differences in breast cancer death rates by age group (P=0.94), more patients over the age of 65 years died from other causes (41/207 [20%] of those older than 65 years vs. 16/471 [3%] of those younger than 65 years; P <.001). In competing risks analyses, older age was associated with non-breast cancer death, whereas larger tumor size was associated with breast cancer death. PgR was positively, and nodal status negatively, associated with survival, regardless of type. In the older patient group, the competing risks analyses identified similar effects for age and tumor size; in addition, higher ER assay values were less likely to be associated with breast cancer death.
With increased lifespan, there will be more breast cancer cases in women older than 65 years; we have shown that women in this group have more non-breast cancer deaths. It becomes important, then, to delineate differential effects of prognostic factors on competing causes of death.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - therapy</subject><subject>Cause of Death</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy</subject><subject>Death</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Life span</subject><subject>Mastectomy</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Regression Analysis</subject><subject>Risk</subject><subject>Survival Analysis</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpdkE1Lw0AQhhdRao1evAsBwYMQnf3eHLVYFQpe9Bw2-6EtTbbuJgf_vSsNCp5mDg_vzPsgdI7hBgPI2_slEAqUAzlAc8wpq5hQ-DDvIFRVE8GP0UlKGwAsKfAZmtWCYSZgjugidDs3rPv30ugxuVQGX1qnh4_Sh1ju4rrT8atso9NpyEhvXDxFR15vkzubZoHelg-vi6dq9fL4vLhbVYZiGCrrOSZWa8Fk2xpgVlEja0qkJRy8Ir7ltdWUYkyxkIo7pYlhpLWqxZoZQwt0tc_dxfA5ujQ03ToZt93q3oUxNbLONahQGbz8B27CGPv8W0MY5kJIlo8U6HpPmRhSis43U7sGQ_PjsfnzmOGLKXJsO2d_0Ukc_Qb0B2qZ</recordid><startdate>199806</startdate><enddate>199806</enddate><creator>Fish, E B</creator><creator>Chapman, J A</creator><creator>Link, M A</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>199806</creationdate><title>Competing causes of death for primary breast cancer</title><author>Fish, E B ; Chapman, J A ; Link, M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-df512daa647bbc04d83c79327d250f82fb59da3311316785e8a2c42bd8b1a4cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - therapy</topic><topic>Cause of Death</topic><topic>Chemotherapy</topic><topic>Combined Modality Therapy</topic><topic>Death</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Life span</topic><topic>Mastectomy</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Regression Analysis</topic><topic>Risk</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fish, E B</creatorcontrib><creatorcontrib>Chapman, J A</creatorcontrib><creatorcontrib>Link, M A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fish, E B</au><au>Chapman, J A</au><au>Link, M A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Competing causes of death for primary breast cancer</atitle><jtitle>Annals of surgical oncology</jtitle><addtitle>Ann Surg Oncol</addtitle><date>1998-06</date><risdate>1998</risdate><volume>5</volume><issue>4</issue><spage>368</spage><epage>375</epage><pages>368-375</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>A patient's likelihood of dying from breast cancer or another cause can be assessed with competing risks analyses.
Data for a cohort of 678 patients with primary invasive breast cancer accrued from 1971 to 1990, updated to 1995, included cause of death (e.g., breast cancer vs. other cause). We investigated the effects of age, tumor size, nodal status, ER, PgR, and adjuvant therapy (hormones, chemotherapy, radiotherapy) on type of death and time to death for patients of all ages and for those over the age of 65 years.
Although there were no significant univariate differences in breast cancer death rates by age group (P=0.94), more patients over the age of 65 years died from other causes (41/207 [20%] of those older than 65 years vs. 16/471 [3%] of those younger than 65 years; P <.001). In competing risks analyses, older age was associated with non-breast cancer death, whereas larger tumor size was associated with breast cancer death. PgR was positively, and nodal status negatively, associated with survival, regardless of type. In the older patient group, the competing risks analyses identified similar effects for age and tumor size; in addition, higher ER assay values were less likely to be associated with breast cancer death.
With increased lifespan, there will be more breast cancer cases in women older than 65 years; we have shown that women in this group have more non-breast cancer deaths. It becomes important, then, to delineate differential effects of prognostic factors on competing causes of death.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>9641460</pmid><doi>10.1007/BF02303502</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 1998-06, Vol.5 (4), p.368-375 |
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| language | eng |
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| subjects | Adult Age Aged Breast cancer Breast Neoplasms - mortality Breast Neoplasms - therapy Cause of Death Chemotherapy Combined Modality Therapy Death Female Health risk assessment Humans Invasiveness Life span Mastectomy Medical prognosis Middle Aged Multivariate Analysis Patients Radiation therapy Regression Analysis Risk Survival Analysis |
| title | Competing causes of death for primary breast cancer |
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