Sex ratio and absence of uniparental disomy in spontaneous abortions with a normal karyotype

A series of spontaneous abortions collected in the South Wales region over a period of 18 months was karyotyped to identify those with a normal chromosome complement. Microsatellite polymorphisms distributed throughout all autosomes were typed by the polymerase chain reaction to determine the parent...

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Bibliographic Details
Published in:Clinical genetics 1998-04, Vol.53 (4), p.258-261
Main Authors: Smith, Martin J, Creasy, Michael R, Clarke, Angus, Upadhyaya, Meena
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - genetics
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Female
genetic imprinting
Genomic Imprinting
Gynecology. Andrology. Obstetrics
Humans
Karyotyping
Male
Medical sciences
Microsatellite Repeats
Pregnancy
Pregnancy. Fetus. Placenta
Sex Ratio
spontaneous abortion
uniparental disomy
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Summary:A series of spontaneous abortions collected in the South Wales region over a period of 18 months was karyotyped to identify those with a normal chromosome complement. Microsatellite polymorphisms distributed throughout all autosomes were typed by the polymerase chain reaction to determine the parental origin of each autosome pair in karyotypically normal spontaneous abortions. In 35 cases biparental inheritance of every autosome pair was demonstrated. The sex ratio of the normal spontaneous abortions of proven biparental origin was 0.77, but this was not significantly different from 1.00.
ISSN:0009-9163
1399-0004
DOI:10.1111/j.1399-0004.1998.tb02692.x