Growth and product formation of actinomycetes cultivated at increased total pressure and oxygen partial pressure

Influence of pressure (P) and oxygen partial pressure (PO2) on cultivation of various Streptomyces spp. and Micromonospora purpurea was examined in pressurized air-lift and stirred tank fermenters. The maximum PO2 was 2100 mbar. Growth and product formation of all cultures tested were markedly influ...

Full description

Saved in:
Bibliographic Details
Published in:Applied microbiology and biotechnology 1990-03, Vol.32 (6), p.674-679
Main Authors: LIEFKE, E, KAISER, D, ONKEN, U
Format: Article
Language:English
Subjects:
Aerobiosis
Bacteriological Techniques - instrumentation
Biological and medical sciences
Biotechnology
Fermentation
Fundamental and applied biological sciences. Psychology
Gentamicins - biosynthesis
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
Micromonospora - drug effects
Micromonospora - growth & development
Micromonospora - metabolism
Micromonospora purpurea
oxygen
Oxygen - pharmacology
Partial Pressure
Pressure
Species Specificity
Streptococcus - drug effects
Streptococcus - growth & development
Streptococcus - metabolism
Streptomyces rimosus
Tetracyclines - biosynthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Influence of pressure (P) and oxygen partial pressure (PO2) on cultivation of various Streptomyces spp. and Micromonospora purpurea was examined in pressurized air-lift and stirred tank fermenters. The maximum PO2 was 2100 mbar. Growth and product formation of all cultures tested were markedly influenced by PO2 higher than 1000 mbar. There is evidence that wild strains are more oxygen tolerant than production strains. At a certain PO2 the metabolic activities of all cultures were inhibited. However, results obtained with S. aureofaciens and S. rimosus indicated an increase in specific product formation rate at elevated pressure. With increase in oxygen tension incorporation of oxygen into tetracycline molecules was enhanced. Since elevated oxygen tension can either show inhibiting effects or may be used for regulation of product formation and selectivity, the influence of PO2 should be determined in an appropriate experimental set-up for each process.
ISSN:0175-7598
1432-0614
DOI:10.1007/BF00164738