Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial retinyl ester response to soybean oil

Background Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post‐prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests. Methods We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid c...

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Bibliographic Details
Published in:European journal of clinical investigation 1998-05, Vol.28 (5), p.407-415
Main Authors: MERO, N, SYVÄNNE, M, ROSSENEU, M, LABEUR, C, HILDEN, H, TASKINEN, M.-R
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein B-100
Apolipoprotein B-48
Apolipoproteins B - blood
Apolipoproteins E - blood
Biological and medical sciences
Cholesterol - blood
Dietary Fats - administration & dosage
Dietary Fats - blood
Fasting
Functional investigation of endocrine glands and genital system
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lipids - blood
Lipoproteins - metabolism
Male
Medical sciences
polyunsaturated fatty acids
post-prandial lipaemia
Postprandial Period
Retinol-Binding Proteins - metabolism
Retinol-Binding Proteins, Plasma
retinyl esters
saturated fatty acids
Soybean Oil - administration & dosage
triglyceride-rich lipoproteins
Triglycerides - blood
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Summary:Background Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post‐prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests. Methods We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid cream meal and a liquid soybean oil meal. The study group consisted of 10 healthy normolipidaemic men. We measured triglycerides (TGs), retinyl esters (REs), apolipoprotein E (apoE), apolipoprotein B‐48 (apoB‐48) and apolipoprotein B‐100 (apoB‐100) in plasma and in triglyceride‐rich lipoprotein (TRL) fractions separated by density‐gradient ultracentrifugation at baseline and 3, 4, 6, and 8 h after the FTTs. Results We observed similar TGs, apoE, apoB‐48 and apoB‐100 responses after all three FTTs, despite the different fatty acid composition of the meals. In contrast, the commonly used marker for exogenous particles, RE, differed clearly when polyunsaturated (soybean oil) and saturated fat (cream or mixed meal) were used. The RE response in plasma (P 
ISSN:0014-2972
1365-2362
DOI:10.1046/j.1365-2362.1998.00309.x