The Effects of Copper, Zinc, Mercury, and Cadmium on Rabbit Erythrocytic Porphobilinogen Synthase In Vivo

The interactions of Zn2+, Hg2+, Cd2+, and Cu2+ with normal and lead-intoxicated rabbit erythrocytic porphobilinogen synthase (PBG-S) were studied in vivo. The results obtained show that each divalent ion has a characteristic effect on the pH-activity relationship of PBG-S. The effects for a given io...

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Bibliographic Details
Published in:Journal of analytical toxicology 1990-07, Vol.14 (4), p.222-226
Main Authors: Farant, Jean-Pierre, Wigfield, Donald C.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cadmium
Cadmium - pharmacology
Cations, Divalent - pharmacology
Chemical and industrial products toxicology. Toxic occupational diseases
Copper
Copper - antagonists & inhibitors
Copper - pharmacology
Enzyme Activation - drug effects
Erythrocytes - drug effects
Erythrocytes - enzymology
Hydrogen-Ion Concentration
Lead
Lead - antagonists & inhibitors
Male
Medical sciences
Mercury
Mercury - pharmacology
Metals - pharmacology
Metals and various inorganic compounds
pH effects
Porphobilinogen synthase
Porphobilinogen Synthase - blood
Rabbits
Toxicology
Zinc
Zinc - pharmacology
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Summary:The interactions of Zn2+, Hg2+, Cd2+, and Cu2+ with normal and lead-intoxicated rabbit erythrocytic porphobilinogen synthase (PBG-S) were studied in vivo. The results obtained show that each divalent ion has a characteristic effect on the pH-activity relationship of PBG-S. The effects for a given ion were both pH and concentration dependent and were similar to those obtained in vitro. Lead was found to be the most potent effector in vivo.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/14.4.222