Sexuality and Management of Benign Prostatic Hyperplasia with Alfuzosin: SAMBA Thailand

Benign prostatic hyperplasia (BPH) is a common condition among elderly men. The aim of therapy is to improve lower urinary tract symptoms (LUTS) and quality of life (QoL) and to prevent complications. The primary objective was to assess the effect on ejaculatory dysfunction (EjD) of 6 months treatme...

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Published in:Journal of sexual medicine 2010-09, Vol.7 (9), p.3115-3126
Main Authors: Leungwattanakij, Somboon, Watanachote, Damrongpun, Noppakulsatit, Patra, Petchpaibuol, T., Choeypunt, Nopporn, Tongbai, Thanasak, Wanamkang, Teerawan, Lojanapiwat, Bunnakij, Permpongkosol, Sompol, Tantiwong, Anupan, Pripatnanont, Chusak, Akarasakul, Danaipan, Kongwiwatanakul, Somsak, Chotikawanich, Ekarat
Format: Article
Language:English
Subjects:
Adrenergic alpha-1 Receptor Antagonists - therapeutic use
Aged
Alpha-Blocker
Benign Prostatic Hyperplasia
Ejaculation
Ejaculation - drug effects
Erectile Dysfunction - drug therapy
Erectile Dysfunction - etiology
Humans
Lower Urinary Tract Symptoms
LUTS
Male
Middle Aged
Nocturia - drug therapy
Prostatic Hyperplasia - complications
Prostatic Hyperplasia - drug therapy
Quinazolines - therapeutic use
Severity of Illness Index
Thailand
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Summary:Benign prostatic hyperplasia (BPH) is a common condition among elderly men. The aim of therapy is to improve lower urinary tract symptoms (LUTS) and quality of life (QoL) and to prevent complications. The primary objective was to assess the effect on ejaculatory dysfunction (EjD) of 6 months treatment with alfuzosin (XATRAL) 10mg once daily (OD) in men with LUTS suggestive of BPH in Thailand. Secondary objectives were to evaluate the efficacy of alfuzosin on LUTS, bother score (International Prostate Symptom Score [IPSS] 8th question), erectile dysfunction (ED), onset of action, and tolerability. Overall, 99 men with moderate to severe LUTS suggestive of BPH (mean IPSS 18.9, bother score 4.3) were enrolled in an open-label study. Sexual function was evaluated at baseline and after 6 months treatment, using the International Index of Erectile Function-5 and the Male Sexual Health Questionnaire (MSHQ) ejaculation score, a new validated questionnaire assessing seven EjD symptoms. The main outcome measure is mean change from baseline to the end of treatment in the MSHQ Ejaculation score. MHSQ ejaculation score significantly improved from 23.09 at baseline to 21.54 at 6 months (P=0.022). Overall, 70% of patients perceived an improvement in LUTS within 1 week (36.3% within 3 days). IPSS total score significantly improved from 18.93 at baseline to 9.59 at 6 months (P
ISSN:1743-6095
1743-6109
DOI:10.1111/j.1743-6109.2010.01743.x