Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110

Human B lymphocytes localize and differentiate within the microenvironment of lymphoid germinal centers. A frozen section binding assay was developed for the identification of those molecules involved in the adhesive interactions between B cells and lymphoid follicles. Activated human B cells and B...

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Published in:Science (American Association for the Advancement of Science) 1990-08, Vol.249 (4972), p.1030-1033
Main Authors: Freedman, Arnold S., Munro, J. Michael, Rice, G. Edgar, Bevilacqua, Michael P., Morimoto, Chikao, McIntyre, Bradley W., Rhynhart, Kurt, Pober, Jordan S., Nadler, Lee M.
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Monoclonal
Antigens, CD - analysis
B cells
B lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - immunology
B-Lymphocytes - ultrastructure
Biological and medical sciences
Butchering
Cell Adhesion
Cell Adhesion Molecules - immunology
Cell lines
Cells, Cultured
Follicles
Follicular dendritic cells
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Immunology
Lymphocytes
Lymphoid organs: ontogeny, organization, homing phenomenon
Lymphoid tissue
Molecular aspects
Molecular biology
Molecules
Palatine Tonsil - cytology
Palatine Tonsil - immunology
Physiological aspects
Receptors, Very Late Antigen - immunology
Spleen - immunology
Vascular Cell Adhesion Molecule-1
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cited_by cdi_FETCH-LOGICAL-c650t-7684c826a673116d1736261048326129ac1089f5d1998c1c125b6b9c84b426783
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container_issue 4972
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container_title Science (American Association for the Advancement of Science)
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creator Freedman, Arnold S.
Munro, J. Michael
Rice, G. Edgar
Bevilacqua, Michael P.
Morimoto, Chikao
McIntyre, Bradley W.
Rhynhart, Kurt
Pober, Jordan S.
Nadler, Lee M.
description Human B lymphocytes localize and differentiate within the microenvironment of lymphoid germinal centers. A frozen section binding assay was developed for the identification of those molecules involved in the adhesive interactions between B cells and lymphoid follicles. Activated human B cells and B cell lines were found to selectively adhere to germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular interaction model can be used for the study of how B cells differentiate.
doi_str_mv 10.1126/science.1697696
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Activated human B cells and B cell lines were found to selectively adhere to germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular interaction model can be used for the study of how B cells differentiate.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>1697696</pmid><doi>10.1126/science.1697696</doi><tpages>4</tpages></addata></record>
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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1990-08, Vol.249 (4972), p.1030-1033
issn 0036-8075
1095-9203
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source American Association for the Advancement of Science; Social Science Premium Collection; JSTOR; Education Collection
subjects Antibodies
Antibodies, Monoclonal
Antigens, CD - analysis
B cells
B lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - immunology
B-Lymphocytes - ultrastructure
Biological and medical sciences
Butchering
Cell Adhesion
Cell Adhesion Molecules - immunology
Cell lines
Cells, Cultured
Follicles
Follicular dendritic cells
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Immunology
Lymphocytes
Lymphoid organs: ontogeny, organization, homing phenomenon
Lymphoid tissue
Molecular aspects
Molecular biology
Molecules
Palatine Tonsil - cytology
Palatine Tonsil - immunology
Physiological aspects
Receptors, Very Late Antigen - immunology
Spleen - immunology
Vascular Cell Adhesion Molecule-1
title Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110
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