C-2 Arylation of Piperidines through Directed Transition-Metal-Catalyzed sp3 CH Activation

All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)H‐activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition‐metal‐catalyzed functi...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2010-11, Vol.16 (44), p.13063-13067
Main Authors: Prokopcová, Hana, Bergman, Sheba D., Aelvoet, Karel, Smout, Veerle, Herrebout, Wouter, Van der Veken, Benjamin, Meerpoel, Lieven, Maes, Bert U. W.
Format: Article
Language:English
Subjects:
Catalysis
CH activation
homogeneous catalysis
hydrogen
Molecular Structure
piperidines
Piperidines - chemistry
ruthenium
Ruthenium - chemistry
Stereoisomerism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)H‐activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition‐metal‐catalyzed functionalizations are still rare. Open‐vial reactions proved crucial to this direct arylation procedure as, upon sealing, catalyst deactivation occurs.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201001887