Vasopressin mediates the inhibitory effect of central angiotensin II on cerebrospinal fluid formation

• Published in: European journal of pharmacology 1998-04, Vol.347 (2), p.205-209
• Main Authors: Chodobski, Adam, Szmydynger-Chodobska, Joanna, Johanson, Conrad E
• Format: Article
• Language: English
• Subjects: Adrenergic Antagonists - pharmacology; Angiotensin II; Angiotensin II - physiology; Animals; Antidiuretic Hormone Receptor Antagonists; Biological and medical sciences; Cerebrospinal Fluid - drug effects; Cerebrospinal Fluid - physiology; Cerebrospinal fluid formation; Choroid plexus; Male; Medical sciences; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems; Pharmacology. Drug treatments; Rat; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin - physiology; Sympathetic nervous system; Sympathetic Nervous System - physiology; Vasopressin; Vasopressins - physiology
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/S0014-2999(98)00229-5

Angiotensin II infused at low doses into the cerebral ventricles decreases cerebrospinal fluid (CSF) production. Since central angiotensin II also activates the sympathetic nervous system and promotes vasopressin release, the roles of these two factors in mediating the inhibitory effect of angiotensin II on CSF formation were studied. CSF production was measured in rats by the ventriculocisternal perfusion method. During central angiotensin II infusion (5 pg min −1), the following adrenoceptor antagonists were administered intravenously (i.v.): phentolamine ( α 1/ α 2, 2 mg/kg per h), prazosin ( α 1, 1 mg/kg per h), and propranolol ( β, 1 mg/kg per h). None of these agents affected the inhibitory effect of angiotensin II on CSF formation. In comparison, in animals administered i.v., the vasopressin V 1 receptor antagonist, d(CH 2) 5Tyr(Me)Arg-vasopressin (10 μg/kg per h), the angiotensin II-induced decrease in CSF production was abolished. Our observations indicate, therefore, that vasopressin mediates the inhibitory effect of central angiotensin II on CSF formation.