Acute Respiratory Acidosis Decreases Left Ventricular Contractility but Increases Cardiac Output in Dogs

To understand the cardiovascular response to respiratory acidosis, we measured hemodynamics, left ventricular pressure, and left ventricular volume (three ultrasonic crystal pairs) during eucapnia and respiratory acidosis in 10 fentanyl-anesthetized open-chest dogs. Left ventricular contractility wa...

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Bibliographic Details
Published in:Circulation research 1990-09, Vol.67 (3), p.628-635
Main Authors: Walley, Keith R, Lewis, Theodore H, Wood, L D.H
Format: Article
Language:English
Subjects:
Acidosis, Respiratory - drug therapy
Acidosis, Respiratory - physiopathology
Acute Disease
Animals
Blood Pressure
Carbon Dioxide - blood
Cardiac Output - drug effects
Dogs
Heart Ventricles - physiopathology
Hemodynamics
Hydrogen-Ion Concentration
Hypercapnia - physiopathology
Myocardial Contraction - drug effects
Oxygen - blood
Propranolol - pharmacology
Propranolol - therapeutic use
Vascular Resistance
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Summary:To understand the cardiovascular response to respiratory acidosis, we measured hemodynamics, left ventricular pressure, and left ventricular volume (three ultrasonic crystal pairs) during eucapnia and respiratory acidosis in 10 fentanyl-anesthetized open-chest dogs. Left ventricular contractility was assessed primarily by measuring the slope (Emax) and intercept (V0) of the left ventricular end-systolic pressure-volume relation determined by combining end-systolic points from a vena caval occlusion and from brief aortic cross-clamping. Respiratory acidosis (pH 7.09, Pco2 92 mm Hg) reduced contractility by a decrease in Emax (11.4 to 9.2 mm Hg/ml, p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.67.3.628