Blood glutamate levels in patients with motor neuron disease

This study was undertaken to evaluate the role of excitatory amino acid glutamate (Glu) in the pathophysiology of motor neuron disease (MND). It was observed that blood Glu levels were significantly higher in MND patients with respect to healthy controls. The data indicate that Glu homeostasis is al...

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Bibliographic Details
Published in:Clinica chimica acta 1998-05, Vol.273 (2), p.195-200
Main Authors: Nagesh Babu, G, Bawari, M, Mathur, V.N, Kalita, J, Misra, U.K
Format: Article
Language:English
Subjects:
Adult
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - blood
Biological and medical sciences
Bulbar Palsy, Progressive - blood
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Excitotoxins
Female
Glutamate
Glutamic Acid - blood
Humans
Male
Medical sciences
Middle Aged
Motor neuron disease
Motor Neuron Disease - blood
Neurology
Progressive bulbar palsy
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Summary:This study was undertaken to evaluate the role of excitatory amino acid glutamate (Glu) in the pathophysiology of motor neuron disease (MND). It was observed that blood Glu levels were significantly higher in MND patients with respect to healthy controls. The data indicate that Glu homeostasis is altered in the patients with MND.
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(98)00039-4