The safety and efficacy of Australian tick-borne disease vaccine strains in cattle in Paraguay

Glycerol preserved, frozen tick-borne disease vaccine strains developed in Australia were imported into Paraguay to test their safety in pregnant Holando heifers and their efficacy against challenge from inoculated local field strains of Babesia bigemina, B. bovis and Anaplasma marginale in Hereford...

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Bibliographic Details
Published in:Veterinary parasitology 1998-03, Vol.76 (1), p.27-41
Main Authors: Brizuela, C.M, Ortellado, C.A, Sanabria, E, Torres, O, Ortigosa, D
Format: Article
Language:English
Subjects:
Anaplasma - immunology
Anaplasma centrale
ANAPLASMA MARGINALE
Anaplasmosis - immunology
Anaplasmosis - prevention & control
Animals
Australia
Babesia - immunology
BABESIA BIGEMINA
BABESIA BOVIS
Babesia bovis - immunology
Babesia spp
Babesiosis - immunology
Babesiosis - prevention & control
Bacterial Vaccines
BOVIN
CATTLE
Cattle Diseases
Cattle-protozoa
Female
GANADO BOVINO
PARAGUAY
Pregnancy
Protozoan Vaccines
Tick Control
Tick-Borne Diseases - immunology
Tick-Borne Diseases - prevention & control
Tick-Borne Diseases - veterinary
VACCIN
VACCINATION
VACCINES
VACUNA
VACUNACION
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Summary:Glycerol preserved, frozen tick-borne disease vaccine strains developed in Australia were imported into Paraguay to test their safety in pregnant Holando heifers and their efficacy against challenge from inoculated local field strains of Babesia bigemina, B. bovis and Anaplasma marginale in Hereford×Criolla heifers. The two Babesia strains proved to be safe and the B. bovis K strain was very effective in providing immunity to a local field strain of B. bovis. The B. bigemina efficacy trial was inconclusive, possibly due to the avirulent nature of the local field strain used in challenge. The A. centrale strain did not prove to be as safe as would be desirable in safety trials, neither did it provide as good protection as the Babesia strains in the efficacy trial. It was concluded that the Babesia strains provided good protection against field challenge in Paraguay and were safe to use in highly susceptible cattle, however an alternative to A. centrale should be sought to provide protection against local strains of A. marginale.
ISSN:0304-4017
1873-2550
DOI:10.1016/S0304-4017(97)00047-2