In Vitro Platelet-Activating Factor Receptor Binding Inhibitory Activity of Pinusolide Derivatives: A Structure−Activity Study

Pinusolide, a labdane-type diterpene lactone isolated from Biota orientalis, was found to be a potent platelet-activating factor (PAF) receptor binding antagonist. To investigate the structure−activity relationship and find derivatives with improved pharmacological profiles, 17 pinusolide derivative...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1998-07, Vol.41 (14), p.2626-2630
Main Authors: Han, Byung Hoon, Yang, Hyun Ok, Kang, Young-Hwa, Suh, Dae-Yeon, Go, Hyun Jung, Song, Wan-Jin, Kim, Yong Chul, Park, Man Ki
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Platelets - drug effects
Blood Platelets - metabolism
Blood. Blood coagulation. Reticuloendothelial system
Diterpenes - chemical synthesis
Diterpenes - chemistry
Diterpenes - pharmacology
In Vitro Techniques
Medical sciences
Pharmacology. Drug treatments
Platelet Activating Factor - metabolism
Platelet Aggregation Inhibitors - chemical synthesis
Platelet Aggregation Inhibitors - chemistry
Platelet Aggregation Inhibitors - pharmacology
Platelet Membrane Glycoproteins - antagonists & inhibitors
Rabbits
Receptors, Cell Surface
Receptors, G-Protein-Coupled
Structure-Activity Relationship
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Summary:Pinusolide, a labdane-type diterpene lactone isolated from Biota orientalis, was found to be a potent platelet-activating factor (PAF) receptor binding antagonist. To investigate the structure−activity relationship and find derivatives with improved pharmacological profiles, 17 pinusolide derivatives were prepared and tested for their ability to inhibit the PAF receptor binding. The results demonstrated that the carboxymethyl ester group at C-19, the integrity of the α,β-unsaturated butenolide ring, and the exocyclic olefinic function of pinusolide are all necessary for its maximum PAF receptor binding inhibitory activity. Among the derivatives, the 17-nor-8-oxo derivative 8 was found to be as potent as pinusolide. The results also suggested that several derivatives warrant further pharmaceutical and pharmacological studies due to their improved water solubility (8 and 11) and apparent lack of susceptibility to Michael-type nucleophilic addition (13 and 18).
ISSN:0022-2623
1520-4804
DOI:10.1021/jm970569j