Psoriasis patients have T-cells with reduced responsiveness to common mycobacterial antigens

Abstract Heparinised blood samples were obtained from 20 patients with chronic plaque psoriasis and from 13 age-matched healthy controls. After preliminary titration, mononuclear cells separated over Ficoll-Tryoson were cultured for 5 days with 10 µg ml−1 of 15 mycobacterial preparations, or with po...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 1998-05, Vol.21 (1), p.65-70
Main Authors: Bay, Maria-Luisa, Lehrer, Amira, Bressanelli, Amalia, Morini, Julio, Bottasso, Oscar, Stanford, John
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Antigens
Antigens, Bacterial - immunology
Arthritis
Biological and medical sciences
Cells, Cultured
Chagas disease
Concanavalin A
Concanavalin A - immunology
Dermatology
Female
HIV
Human immunodeficiency virus
Humans
Immunotherapy
Leukocytes (mononuclear)
Lymphocyte Activation
Lymphocyte transformation
Lymphocytes T
Male
Matched-Pair Analysis
Medical sciences
Mitogens
Mycobacterial antigen
Mycobacterium - immunology
Pokeweed mitogen
Pokeweed Mitogens - immunology
Psoriasis
Psoriasis - blood
Psoriasis - immunology
Psoriasis. Parapsoriasis. Lichen
Reagents
Relationship to etiology
Rheumatoid arthritis
Skin diseases
T-Lymphocytes - immunology
Titration
Vector-borne diseases
Viruses
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Summary:Abstract Heparinised blood samples were obtained from 20 patients with chronic plaque psoriasis and from 13 age-matched healthy controls. After preliminary titration, mononuclear cells separated over Ficoll-Tryoson were cultured for 5 days with 10 µg ml−1 of 15 mycobacterial preparations, or with pokeweed mitogen and concanavalin A. Stimulation indices were determined for each reagent and means were determined for patients and controls. Results for patients showed a striking reduction of responsiveness to mycobacteria, apparently due to loss of responses to group i, common mycobacterial antigens, and no differences in responses to mitogens. These observations relate psoriasis to certain other diseases, notably mycobacterial infections, rheumatoid arthritis, Chagas' disease and human immunodeficiency virus infection. The observations may be relevant to the aetiology of psoriasis, and to potential immunotherapy for the disease.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.1998.tb01150.x