Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells

Human MutT homologue ( hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of hMTH1 mRNA were inversely proportional...

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Bibliographic Details
Published in:FEBS letters 1998-06, Vol.429 (1), p.17-20
Main Authors: Kennedy, Christopher H, Cueto, Rafael, Belinsky, Steven A, Lechner, John F, Pryor, William A
Format: Article
Language:English
Subjects:
8-Oxo-deoxyguanosine
Adaptor Proteins, Signal Transducing
Biomarkers, Tumor - metabolism
Fungal Proteins - genetics
Fungal Proteins - metabolism
Gene expression
Human MutT homologue
Humans
Lung cancer
Lung Neoplasms - metabolism
Membrane Proteins
Molecular marker
Neoplasm Proteins - metabolism
Oxidative Stress
RNA, Messenger - metabolism
Saccharomyces cerevisiae Proteins
Tumor Cells, Cultured
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Summary:Human MutT homologue ( hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of hMTH1 mRNA were inversely proportional to cellular levels of 8-oxo-deoxyguanosine. Together, these results suggest that hMTH1 gene expression may represent a molecular marker of oxidative stress that could ultimately be used to elucidate the temporal relationships between oxidative stress, genomic instability and the development of lung cancer.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)00505-5