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Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells
Human MutT homologue ( hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of hMTH1 mRNA were inversely proportional...
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| Published in: | FEBS letters 1998-06, Vol.429 (1), p.17-20 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4915-65251018f9c75605ebbdcf829702dbccbe73f23625892af3474afc0ba99290d93 |
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| cites | cdi_FETCH-LOGICAL-c4915-65251018f9c75605ebbdcf829702dbccbe73f23625892af3474afc0ba99290d93 |
| container_end_page | 20 |
| container_issue | 1 |
| container_start_page | 17 |
| container_title | FEBS letters |
| container_volume | 429 |
| creator | Kennedy, Christopher H Cueto, Rafael Belinsky, Steven A Lechner, John F Pryor, William A |
| description | Human
MutT homologue (
hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of
hMTH1 mRNA were inversely proportional to cellular levels of 8-oxo-deoxyguanosine. Together, these results suggest that
hMTH1 gene expression may represent a molecular marker of oxidative stress that could ultimately be used to elucidate the temporal relationships between oxidative stress, genomic instability and the development of lung cancer. |
| doi_str_mv | 10.1016/S0014-5793(98)00505-5 |
| format | article |
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MutT homologue (
hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of
hMTH1 mRNA were inversely proportional to cellular levels of 8-oxo-deoxyguanosine. Together, these results suggest that
hMTH1 gene expression may represent a molecular marker of oxidative stress that could ultimately be used to elucidate the temporal relationships between oxidative stress, genomic instability and the development of lung cancer.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(98)00505-5</identifier><identifier>PMID: 9657375</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>8-Oxo-deoxyguanosine ; Adaptor Proteins, Signal Transducing ; Biomarkers, Tumor - metabolism ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; Gene expression ; Human MutT homologue ; Humans ; Lung cancer ; Lung Neoplasms - metabolism ; Membrane Proteins ; Molecular marker ; Neoplasm Proteins - metabolism ; Oxidative Stress ; RNA, Messenger - metabolism ; Saccharomyces cerevisiae Proteins ; Tumor Cells, Cultured</subject><ispartof>FEBS letters, 1998-06, Vol.429 (1), p.17-20</ispartof><rights>1998 Federation of European Biochemical Societies</rights><rights>FEBS Letters 429 (1998) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4915-65251018f9c75605ebbdcf829702dbccbe73f23625892af3474afc0ba99290d93</citedby><cites>FETCH-LOGICAL-c4915-65251018f9c75605ebbdcf829702dbccbe73f23625892af3474afc0ba99290d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579398005055$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9657375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kennedy, Christopher H</creatorcontrib><creatorcontrib>Cueto, Rafael</creatorcontrib><creatorcontrib>Belinsky, Steven A</creatorcontrib><creatorcontrib>Lechner, John F</creatorcontrib><creatorcontrib>Pryor, William A</creatorcontrib><title>Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Human
MutT homologue (
hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of
hMTH1 mRNA were inversely proportional to cellular levels of 8-oxo-deoxyguanosine. Together, these results suggest that
hMTH1 gene expression may represent a molecular marker of oxidative stress that could ultimately be used to elucidate the temporal relationships between oxidative stress, genomic instability and the development of lung cancer.</description><subject>8-Oxo-deoxyguanosine</subject><subject>Adaptor Proteins, Signal Transducing</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Fungal Proteins - genetics</subject><subject>Fungal Proteins - metabolism</subject><subject>Gene expression</subject><subject>Human MutT homologue</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - metabolism</subject><subject>Membrane Proteins</subject><subject>Molecular marker</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Oxidative Stress</subject><subject>RNA, Messenger - metabolism</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>Tumor Cells, Cultured</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOxCAUhonR6Dj6CCasjC6q0JYCbsxoHMfES-Jl4YpQeqpoLyNMR3176czEra4I_BfO-RDao-SIEpodPxBC04hxmRxIcUgIIyxia2hABU-iJM3EOhr8WrbQtvdvJNwFlZtoU2aMJ5wN0PPdHBx8TR14b9sGtyV-vXmcUFzf345OsMZ1W4HpKu1wrd07uN7RftlCz-wcsJ_1QWwbXHXNCza6McFioKr8DtoodeVhd3UO0dP44vF8El3fXV6dj64jk0rKoozFLOwjSmk4ywiDPC9MKWLJSVzkxuTAkzJOspgJGesySXmqS0NyLWUsSSGTIdpf9k5d-9GBn6na-n4C3UDbecWlDEREb2RLo3Gt9w5KNXU2LPWtKFE9UrVAqnpeSgq1QKpYyO2tPujyGorf1Iph0CdL_dNW8P2_UjW-OIsXSi9IsXjuq06XVRCAzS045Y2FwLSwDsxMFa39Y9gfTWSZMQ</recordid><startdate>19980605</startdate><enddate>19980605</enddate><creator>Kennedy, Christopher H</creator><creator>Cueto, Rafael</creator><creator>Belinsky, Steven A</creator><creator>Lechner, John F</creator><creator>Pryor, William A</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980605</creationdate><title>Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells</title><author>Kennedy, Christopher H ; Cueto, Rafael ; Belinsky, Steven A ; Lechner, John F ; Pryor, William A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4915-65251018f9c75605ebbdcf829702dbccbe73f23625892af3474afc0ba99290d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>8-Oxo-deoxyguanosine</topic><topic>Adaptor Proteins, Signal Transducing</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Fungal Proteins - genetics</topic><topic>Fungal Proteins - metabolism</topic><topic>Gene expression</topic><topic>Human MutT homologue</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - metabolism</topic><topic>Membrane Proteins</topic><topic>Molecular marker</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Oxidative Stress</topic><topic>RNA, Messenger - metabolism</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kennedy, Christopher H</creatorcontrib><creatorcontrib>Cueto, Rafael</creatorcontrib><creatorcontrib>Belinsky, Steven A</creatorcontrib><creatorcontrib>Lechner, John F</creatorcontrib><creatorcontrib>Pryor, William A</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kennedy, Christopher H</au><au>Cueto, Rafael</au><au>Belinsky, Steven A</au><au>Lechner, John F</au><au>Pryor, William A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1998-06-05</date><risdate>1998</risdate><volume>429</volume><issue>1</issue><spage>17</spage><epage>20</epage><pages>17-20</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Human
MutT homologue (
hMTH1) mRNA was overexpressed in SV-40-transformed non-tumorigenic human bronchial epithelial cells (BEAS-2B cells) and in 11 out of 12 human lung cancer cell lines relative to normal human bronchial epithelial cells. Expression levels of
hMTH1 mRNA were inversely proportional to cellular levels of 8-oxo-deoxyguanosine. Together, these results suggest that
hMTH1 gene expression may represent a molecular marker of oxidative stress that could ultimately be used to elucidate the temporal relationships between oxidative stress, genomic instability and the development of lung cancer.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>9657375</pmid><doi>10.1016/S0014-5793(98)00505-5</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1998-06, Vol.429 (1), p.17-20 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79987389 |
| source | ScienceDirect Journals; Wiley-Blackwell Read & Publish Collection |
| subjects | 8-Oxo-deoxyguanosine Adaptor Proteins, Signal Transducing Biomarkers, Tumor - metabolism Fungal Proteins - genetics Fungal Proteins - metabolism Gene expression Human MutT homologue Humans Lung cancer Lung Neoplasms - metabolism Membrane Proteins Molecular marker Neoplasm Proteins - metabolism Oxidative Stress RNA, Messenger - metabolism Saccharomyces cerevisiae Proteins Tumor Cells, Cultured |
| title | Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells |
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