African swine fever virus infection of the bushpig ( Potamochoerus porcus) and its significance in the epidemiology of the disease

• Published in: Veterinary microbiology 1998-04, Vol.62 (1), p.1-15
• Main Authors: Anderson, E.C, Hutchings, G.H, Mukarati, N, Wilkinson, P.J
• Format: Article
• Language: English
• Subjects: Africa - epidemiology; African swine fever; African Swine Fever - epidemiology; African Swine Fever - transmission; African Swine Fever - virology; AFRICAN SWINE FEVER VIRUS; African Swine Fever Virus - immunology; African Swine Fever Virus - isolation & purification; African Swine Fever Virus - physiology; Animal viral diseases; Animals; Animals, Wild; Arachnid Vectors - virology; Biological and medical sciences; Bushpig; Cells, Cultured; CERDO; Endothelium, Vascular - cytology; Endothelium, Vascular - virology; Enzyme-Linked Immunosorbent Assay - veterinary; EPIDEMIOLOGIA; EPIDEMIOLOGIE; EPIDEMIOLOGY; Fundamental and applied biological sciences. Psychology; Infectious diseases; Leukocytes - virology; Macrophages, Alveolar - virology; Medical sciences; Microbiology; PORCIN; SWINE; Ticks - virology; Viral diseases; Viremia - epidemiology; Viremia - transmission; Viremia - virology; Virology; VIRUS DE LA PESTE PORCINA AFRICANA; VIRUS PESTE PORCINE AFRICAINE; Virus Replication
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/S0378-1135(98)00187-4

Warthog ( Phacochoerus aethiopicus), giant forest hog ( Hylochoerus meinertzhageni) and bushpig ( Potamochoerus porcus) are known to be susceptible to infection with African swine fever (ASF) virus. Little however, is known about the ecology of the disease in the bushpig. This study has shown that the bushpig remains viraemic for between 35 and 91 days following infection during which time it is able to infect the tick vector O. moubata. These ticks were able to transmit the disease to pigs. The virus persists in the lymphatic tissues for less than 34 weeks. Bushpigs infected with LIL 20/1 virus but not VIC T90/1 virus transmitted infection to in-contact pigs. Infected domestic pigs did not transmit the infection to in-contact bushpigs. ASF virus was able to replicate in in vitro cultures of bushpig leucocytes and endothelial cells. Recovered bushpigs could be re-infected with some strains of virus but not others. While it has been demonstrated that bushpigs remain carriers of ASFV following infection a complete understanding of their significance in the epidemiology of the disease awaits further investigations of their association with O. moubata.