CT and MR imaging of cerebral tuberous sclerosis

Tuberous sclerosis is a heredofamilial neurocutaneous syndrome, or phakomatosis, with multisystem involvement including the brain, kidney, skin, retina, heart, lung, and bone. The brain is the most frequently affected organ in tuberous sclerosis. Brain lesions in tuberous sclerosis are of three kind...

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Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 1998-06, Vol.20 (4), p.209-221
Main Authors: Inoue, Yuichi, Nemoto, Yutaka, Murata, Ryuusuke, Tashiro, Takahiko, Shakudo, Miyuki, Kohno, Kinuko, Matsuoka, Osamu, Mochizuki, Kunizo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - diagnostic imaging
Brain - pathology
Cortical tuber
Humans
Magnetic Resonance Imaging
Medical sciences
Mental retardation
Neurology
Seizures
Subependymal giant cell tumor
Subependymal nodule
Tomography, X-Ray Computed
Tuberous sclerosis
Tuberous Sclerosis - diagnosis
Tumors of the nervous system. Phacomatoses
White matter tuber
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Summary:Tuberous sclerosis is a heredofamilial neurocutaneous syndrome, or phakomatosis, with multisystem involvement including the brain, kidney, skin, retina, heart, lung, and bone. The brain is the most frequently affected organ in tuberous sclerosis. Brain lesions in tuberous sclerosis are of three kinds; cortical tubers, white matter abnormalities, and subependymal nodules. We review the computed tomography (CT) and magnetic resonance (MR) features of the brain lesions in patients with tuberous sclerosis. CT clearly demonstrates calcified subependymal nodules. MR imaging demonstrates more clearly cortical, and white matter lesions than CT, since MR imaging shows excellent image contrast between various normal structures and high sensitivity in detecting pathological states due to intrinsic differences in proton density and in particular, in proton relaxation times of tissues. Possible pathogenesis of this disorder is also discussed
ISSN:0387-7604
1872-7131
DOI:10.1016/S0387-7604(98)00022-9