From cows stem therapies?

The embryonic stem (ES) cell has been a remarkably successful tool for creating transgenic and knockout animals. Indeed, genetic manipulation of ES cells remains the only routine method of carrying out specific genetic targeting (homologous recombination) at precise chromosomal locations in mice. In...

Full description

Saved in:
Bibliographic Details
Published in:Nature biotechnology 1998-07, Vol.16 (7), p.620-621
Main Authors: First, Neal L., Thomson, James
Format: Article
Language:English
Subjects:
Agriculture
analysis
Animals
Animals, Genetically Modified
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Blastocyst - physiology
Cattle - genetics
Cell Line
Chimera
Genetic Therapy
Humans
Life Sciences
Microinjections - methods
Oocytes - physiology
Stem Cells - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The embryonic stem (ES) cell has been a remarkably successful tool for creating transgenic and knockout animals. Indeed, genetic manipulation of ES cells remains the only routine method of carrying out specific genetic targeting (homologous recombination) at precise chromosomal locations in mice. In this issue, Cibelli et al. report the first pluripotent cells isolated from a bovine species that have the potential to form chimeras. These pluripotent bovine cells not only have potential for generating organs/tissues for use in xenotransplantation, but also bring closer the intriguing possibility of human ES cell lines for use in therapeutic applications.
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt0798-620