Cobalamin Deficiency: MRI Detection of Posterior Columns Involvement and Posttreatment Resolution

Cobalamin‐deficient myelopathy is a neurologic disorder manifesting progressive symptoms of paresthesiae and spastic paralysis. The pathologic changes initially involve the posterior columns of the cervical and upper thoracic cord. The authors present the case of a patient with cobalamin deficiency...

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Bibliographic Details
Published in:Journal of neuroimaging 1998-07, Vol.8 (3), p.171-173
Main Authors: Karacostas, Dimitris, Artemis, Nikos, Bairactaris, Chris, Tsitourides, Ioannis, Milonas, Ioannis
Format: Article
Language:English
Subjects:
Follow-Up Studies
Humans
Injections, Intramuscular
Magnetic Resonance Imaging
Male
Middle Aged
Paraplegia - diagnosis
Paraplegia - drug therapy
Paresthesia - diagnosis
Paresthesia - drug therapy
Spinal Cord - pathology
Treatment Outcome
Vitamin B 12 - administration & dosage
Vitamin B 12 Deficiency - diagnosis
Vitamin B 12 Deficiency - drug therapy
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Description
Summary:Cobalamin‐deficient myelopathy is a neurologic disorder manifesting progressive symptoms of paresthesiae and spastic paralysis. The pathologic changes initially involve the posterior columns of the cervical and upper thoracic cord. The authors present the case of a patient with cobalamin deficiency with preferential posterior columns involvement as evidenced by spinal magnetic resonance imaging findings. Marked clinical and radiographic resolution occurred after administration of vitamin B12. Early recognition of this specific magnetic resonance pattern is essential, because complete recovery can be achieved with prompt treatment at this reversible stage of the disease. Key words: cobalamin, MRI, myelopathy, vitamin B12.
ISSN:1051-2284
1552-6569
DOI:10.1111/jon199883171