Copper, iron and zinc in Alzheimer's disease senile plaques

Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle...

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Bibliographic Details
Published in:Journal of the neurological sciences 1998-06, Vol.158 (1), p.47-52
Main Authors: Lovell, M.A, Robertson, J.D, Teesdale, W.J, Campbell, J.L, Markesbery, W.R
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amygdala - chemistry
Amygdala - pathology
Biological and medical sciences
Biotinylation
Copper
Copper - analysis
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Humans
Iron
Iron - analysis
Medical sciences
Micro-PIXE analysis
Neurology
Neuropil - chemistry
Neuropil - pathology
Plaque, Amyloid - chemistry
Plaque, Amyloid - pathology
Senile plaques
Spectrometry, X-Ray Emission
Zinc
Zinc - analysis
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Summary:Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil ( P
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(98)00092-6