5-Hydroxy-3, 4, 7-triphenyl-2, 6-benzofurandione, a New Xanthine Oxidase Inhibitor from Peniophora sanguinea

In the course of our screening for new inhibitors of xanthine oxidase (XO) we found the extract of a wood-rotting fungus, Peniophora sanguinea super(1 approximately 3)) to contain an active principle during the common lucigenin-coupled assay of this enzyme. super(4)) Xanthine oxidase was selected as...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1998/05/25, Vol.51(5), pp.528-530
Main Authors: HÄRTL, ALBERT, STELZNER, A., RITZAU, MICHAEL, HEINZE, STEFAN, GRÄFE, UDO
Format: Article
Language:English
Subjects:
Basidiomycota - chemistry
Benzofurans - chemistry
Benzofurans - pharmacology
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Luminescent Measurements
Molecular Structure
Peniophora sanguinea
Spectrum Analysis
Xanthine Oxidase - antagonists & inhibitors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the course of our screening for new inhibitors of xanthine oxidase (XO) we found the extract of a wood-rotting fungus, Peniophora sanguinea super(1 approximately 3)) to contain an active principle during the common lucigenin-coupled assay of this enzyme. super(4)) Xanthine oxidase was selected as a screening target due to its role in nucleic acid metabolism, hyperuricemia (gout), acute pancreatitis, cholecystitis, adult respiratory distress syndrome, its important contribution to superoxide anion radical formation and related disorders such as mycocardidal damage during ischemia and/or reperfusion injury, bacterial translocation from the gastrointestinal tract and several other diseases as well super(5 approximately 8)). Due to severe adverse effects of the therapeutically used inhibitor allopurinol there is an urgent demand for new natural products as XO inhibitors having non-purine structures super(8)). In this paper we describe the isolation, physico-chemical properties, structure elucidation and biological activities of 5-hydroxy-3,4,7-triphenyl-2,6-benzofurandione (1; C sub(27)H sub(18)O sub(4)) from the fruiting bodies of this fungus corproducing xylerythrin (2) super(1,2,4)).
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.528