Total Structures of Colistin Minor Components

Structural characterization of the colistin (CL) components were carried out using Frit-fast atom bombardment liquid chromatography/mass spectrometry (Frit-FAB LC/MS), tandem mass spectrometry (MS/MS) and the amino acid analysis proposed by MARFEY, and the total structures of 4 minor components incl...

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Bibliographic Details
Published in:Journal of antibiotics 1998/05/25, Vol.51(5), pp.492-498
Main Authors: IKAI, YOSHITOMO, OKA, HISAO, HAYAKAWA, JUNKO, KAWAMURA, NORIHISA, MAYUMI, TSUYOSHI, SUZUKI, MAKOTO, HARADA, KEN-ICHI
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Chromatography, Liquid - methods
Colistin - chemistry
Mass Spectrometry - methods
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
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Summary:Structural characterization of the colistin (CL) components were carried out using Frit-fast atom bombardment liquid chromatography/mass spectrometry (Frit-FAB LC/MS), tandem mass spectrometry (MS/MS) and the amino acid analysis proposed by MARFEY, and the total structures of 4 minor components including the absolute configuration of the constituent amino acids were proposed. The structures of the minor components were the same as those of the main component colistin A or B except that L-leucine is replaced by L-valine or L-isoleucine.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.492