Topographical distribution of 5-HT3 receptor recognition sites in the ferret brain stem

The distribution of [3H]zacopride (1.0 nM) to putative 5-HT3 receptor recognition sites in the ferret hindbrain was assessed using autoradiography. Specific binding (defined by the inclusion of granisetron, 1.0 microM) was heterogeneously distributed with highest density within the dorsal vagal comp...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1990-07, Vol.342 (1), p.17-21
Main Authors: Barnes, J M, Barnes, N M, Costall, B, Naylor, I L, Naylor, R J, Rudd, J A
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Benzamides
Brain Stem - anatomy & histology
Brain Stem - metabolism
Bridged Bicyclo Compounds
Bridged Bicyclo Compounds, Heterocyclic
Ferrets
Male
Medulla Oblongata - anatomy & histology
Medulla Oblongata - metabolism
Receptors, Serotonin - metabolism
Serotonin Antagonists
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Summary:The distribution of [3H]zacopride (1.0 nM) to putative 5-HT3 receptor recognition sites in the ferret hindbrain was assessed using autoradiography. Specific binding (defined by the inclusion of granisetron, 1.0 microM) was heterogeneously distributed with highest density within the dorsal vagal complex (area postrema, nucleus tractus solitarius and dorsal motor nucleus of the vagus nerve). Lower densities were detected in the spinal trigeminal nerve complex whilst no other significant specific binding was detected ventral to the dorsal vagal complex. The location of 5-HT3 receptor recognition sites within the dorsal vagal complex may provide sites of action for zacopride and other 5-HT3 receptor antagonists to inhibit the emesis induced by cancer chemotherapeutic agents and x-radiation.
ISSN:0028-1298
1432-1912
DOI:10.1007/bf00178966