Human Rectal Absorption of Short- and Medium-chain C2-C10 Fatty Acids

Background: Current knowledge on the colonorectal absorption of medium-chain fatty acids is limited. The purpose of the present study was to evaluate and compare the human rectal absorption of short- and medium-chain C2-C10 fatty acids in healthy volunteers. Methods: Dialysis bags containing 20 mmol...

Full description

Saved in:
Bibliographic Details
Published in:Scandinavian journal of gastroenterology 1998, Vol.33 (6), p.590-594
Main Authors: JØRGENSEN, J, HOLTUG, K, JEPPESEN, P. B, MORTENSEN, P. B
Format: Article
Language:English
Subjects:
Administration, Rectal
Adult
Biological and medical sciences
Fatty Acids - administration & dosage
Fatty Acids - pharmacokinetics
Fatty Acids, Volatile - administration & dosage
Fatty Acids, Volatile - pharmacokinetics
Female
Fundamental and applied biological sciences. Psychology
Humans
Intestinal Absorption - physiology
Intestinal Mucosa - metabolism
Intestine. Mesentery
Isotonic Solutions - administration & dosage
Isotonic Solutions - pharmacokinetics
Male
Rectum - metabolism
Vertebrates: digestive system
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Current knowledge on the colonorectal absorption of medium-chain fatty acids is limited. The purpose of the present study was to evaluate and compare the human rectal absorption of short- and medium-chain C2-C10 fatty acids in healthy volunteers. Methods: Dialysis bags containing 20 mmol·l-1 of the fatty acids acetate, butyrate, hexanoate, octanoate, or decanoate in a phosphate-buffered (pH neutral) isoosmotic electrolyte solution were placed in the rectum for 30 min in 14 healthy volunteers. Absorption rates were calculated for all fatty acids, sodium, potassium, and water. Results
ISSN:0036-5521
1502-7708
DOI:10.1080/00365529850171846