A Priori Estimation of Phylogenetic Information Conserved in Aligned Sequences

A new phenomenological approach to explorative data analysis, the estimation of spectra of supporting positions, allows the search for conserved tracks left by phylogeny in DNA sequences. Spectra of supporting positions can be generated without reference to a tree topology or a model of sequence evo...

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Bibliographic Details
Published in:Molecular phylogenetics and evolution 1998-06, Vol.9 (3), p.358-365
Main Authors: Wägele, Johann-Wolfgang, Rödding, Friederike
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Conserved Sequence
DNA, Ribosomal - chemistry
DNA, Ribosomal - genetics
Evolution, Molecular
Humans
Molecular Sequence Data
Phylogeny
RNA, Ribosomal, 18S - genetics
Sequence Alignment
Sequence Homology, Nucleic Acid
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Summary:A new phenomenological approach to explorative data analysis, the estimation of spectra of supporting positions, allows the search for conserved tracks left by phylogeny in DNA sequences. Spectra of supporting positions can be generated without reference to a tree topology or a model of sequence evolution and are therefore an ideal tool for a priori estimation of information content of data sets. Analysis of published 18S rDNA alignments shows that signal to noise relationship varies greatly in a way not detected by conventional tree-construction methods.
ISSN:1055-7903
1095-9513
DOI:10.1006/mpev.1998.0501