Relationship of Normal Serum Vitamin B12 and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression

This retrospective study evaluated the relationships between normal serum vitamin B12 and folate levels and neuropsy chologic measures in a sample of 60 geriatric inpatients with psychotic depression, nonpsychotic depression, bipolar dis order, and dementia—all consecutively referred for cognitive t...

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Bibliographic Details
Published in:Journal of geriatric psychiatry and neurology 1990-04, Vol.3 (2), p.98-105
Main Authors: Bell, Iris R., Edman, Joel S., Miller, Joshua, Hebben, Nancy, Linn, Richard T., Ray, Diane, Kayne, Herbert L.
Format: Article
Language:English
Subjects:
Aged
Bipolar Disorder - blood
Bipolar Disorder - diagnosis
Cognition Disorders - blood
Dementia - blood
Dementia - diagnosis
Depressive Disorder - blood
Depressive Disorder - diagnosis
Female
Folic Acid - blood
Humans
Male
Neurocognitive Disorders - blood
Neurocognitive Disorders - diagnosis
Neuropsychological Tests
Psychometrics
Vitamin B 12 - blood
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Summary:This retrospective study evaluated the relationships between normal serum vitamin B12 and folate levels and neuropsy chologic measures in a sample of 60 geriatric inpatients with psychotic depression, nonpsychotic depression, bipolar dis order, and dementia—all consecutively referred for cognitive testing. The psychotic depression subgroup demonstrated numerous significant positive correlations between B12 and cognitive subtests not seen in other diagnostic subgroups, especially those of IQ, and verbal and visual memory. Metabolic factors including vitamin B12 may play specific roles in the cognitive dysfunctions of different geropsychiatric disorders.
ISSN:0891-9887
1552-5708
DOI:10.1177/089198879000300208