Adenosine mediates spinal norepinephrine-produced antinociception as revealed by nociceptive discharges in parafascicular neurons in rats

The effects of intrathecal pretreatment with aminophylline on intrathecal norepinephrine-produced or serotonin-produced suppression of noxiously evoked discharges in thalamic parafascicular neurons were investigated in 35 urethane-anesthetized rats. The results showed that: (1) both intrathecal nore...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 1998-07, Vol.798 (1), p.320-324
Main Authors: Yang, Shou-wei, Liu, Rong-jian, Qiao, Jian-tian, Laufman, Larry E, Dafny, Nachum
Format: Article
Language:English
Subjects:
Adenosine - pharmacology
Aminophylline
Aminophylline - administration & dosage
Aminophylline - pharmacology
Animals
Biological and medical sciences
Electrophysiology
Female
Fundamental and applied biological sciences. Psychology
Injections, Spinal
Intrathecal administration
Male
Neurons - physiology
Nociceptive discharge
Nociceptors - drug effects
Norepinephrine
Norepinephrine - administration & dosage
Norepinephrine - pharmacology
Parafascicular neuron
Rat
Rats
Rats, Sprague-Dawley
Serotonin
Serotonin - administration & dosage
Serotonin - pharmacology
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Thalamus - cytology
Thalamus - physiology
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of intrathecal pretreatment with aminophylline on intrathecal norepinephrine-produced or serotonin-produced suppression of noxiously evoked discharges in thalamic parafascicular neurons were investigated in 35 urethane-anesthetized rats. The results showed that: (1) both intrathecal norepinephrine (15 nmol) or serotonin (20 nmol) produced significant suppression of noxiously evoked discharges in parafascicular neurons; (2) intrathecal aminophylline (120 nmol) blocked the norepinephrine-produced suppression of noxiously evoked discharges, while the same dose of aminophylline exhibited no significant effect on the serotonin-produced suppression of these discharges in parafascicular neurons. The results suggest that spinal norepinephrine-produced, but not serotonin-produced, antinociceptive effects may be mediated by adenosine as one of successive chemical links in the spinal dorsal horn circuitry.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00435-1