Il-6 in a pleomorphic type of malignant fibrous histiocytoma presenting high fever

We describe a rare case of pleomorphic type of malignant fibrous histiocytoma (MFH) in the buttock that presented a systemic involvement. The case was of a 58-year-old woman presenting hepatic dysfunction and inflammatory reactions including fever, positive C-reactive protein (CRP), an elevated eryt...

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Bibliographic Details
Published in:Human pathology 1998-07, Vol.29 (7), p.758-761
Main Authors: Hamada, Tetsuya, Komiya, Setsuro, Hiraoka, Koji, Zenmyo, Michihisa, Morimatsu, Minoru, Inoue, Akio
Format: Article
Language:English
Subjects:
Biological and medical sciences
Buttocks
cytokine
Dermatology
Female
fever
Fever - etiology
Fever - pathology
Histiocytoma, Benign Fibrous - metabolism
Histiocytoma, Benign Fibrous - pathology
Histiocytoma, Benign Fibrous - surgery
Humans
IL-6
Immunoenzyme Techniques
Interleukin-1 - metabolism
Interleukin-6 - metabolism
malignant fibrous histiocytoma
Medical sciences
Middle Aged
Soft Tissue Neoplasms - metabolism
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - surgery
thrombocytosis
Tumor Necrosis Factor-alpha - metabolism
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:We describe a rare case of pleomorphic type of malignant fibrous histiocytoma (MFH) in the buttock that presented a systemic involvement. The case was of a 58-year-old woman presenting hepatic dysfunction and inflammatory reactions including fever, positive C-reactive protein (CRP), an elevated erythrocyte sedimentation rate, and high levels of platelets and ferritin. The fever of 3 months duration subsided on the first postoperative day. The MFH resection also brought rapid normalization in CRP, platelets, and leukocytes. The local and systemic productions of cytokines induced by this tumor were evaluated. In vivo and in vitro production of interleukin (IL)-6, IL-1β, and tumor necrosis factor a by tumor cells were measured using enzyme-linked inununosorbent assay. Blood samples taken preoperatively, tumor tissues, and the primary culture medium showed extraordinarily high IL-6 levels. The plasma IL-6 level was normalized postoperatively. Immunohistochemistry showed the positivity of tumor cells for IL-6. The IL-6 produced by the tumor was concluded to have been responsible for the systemic illness.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(98)90288-X