Mapping Quantitative Trait Loci for Immune Capacity in the Pig

Immune capacity traits show considerable genetic variation in outbred populations. To identify quantitative trait loci (QTLs) for immune capacity in the pig, various measures of immune function (total and differential leukocyte counts, neutrophil phagocytosis, mitogen-induced proliferation, IL-2 pro...

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Bibliographic Details
Published in:The Journal of immunology (1950) 1998-07, Vol.161 (2), p.829-835
Main Authors: Edfors-Lilja, Inger, Wattrang, Eva, Marklund, Lena, Moller, Maria, Andersson-Eklund, Lena, Andersson, Leif, Fossum, Caroline
Format: Article
Language:English
Subjects:
Animals
Antigens, Bacterial - immunology
Chromosome Mapping
Chromosomes - genetics
Chromosomes - immunology
Crosses, Genetic
Escherichia coli - immunology
Female
Herpesvirus 1, Suid - immunology
Immunoglobulin G - biosynthesis
Immunoglobulin G - blood
Interferon-alpha - biosynthesis
Interleukin-2 - biosynthesis
Leukocyte Count
Lymphocyte Activation - genetics
Lymphocyte Activation - immunology
Lymphocytes - immunology
Neutrophils - immunology
Phagocytosis - genetics
Phagocytosis - immunology
Quantitative Trait, Heritable
Swine - genetics
Swine - immunology
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Summary:Immune capacity traits show considerable genetic variation in outbred populations. To identify quantitative trait loci (QTLs) for immune capacity in the pig, various measures of immune function (total and differential leukocyte counts, neutrophil phagocytosis, mitogen-induced proliferation, IL-2 production, and virus induced IFN-alpha production in whole blood cultures, and Ab responses to two Escherichia coli antigens) were determined in 200 F2 animals from a wild pig-Swedish Yorkshire intercross. The pedigree has been typed for 236 genetic markers covering all autosomes, the X chromosome and the X/Y pseudoautosomal region. Through interval mapping using a least-squares method, four QTLs with significant effects were identified; one for total leukocyte counts, one for mitogen-induced proliferation, one for prevaccination levels of Abs to E. coli Ag K88, and one for Ab response to the O149 Ag. In addition, several putative QTLs were indicated. The results from the present study conclusively show that it is possible to identify QTLs for immune capacity traits in outbred pig populations by genome analysis.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.161.2.829