G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions

G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological...

Full description

Saved in:
Bibliographic Details
Published in:FEBS Letters 1998-06, Vol.430 (1), p.37-40
Main Authors: Aragay, Anna M., Ruiz-Gómez, Ana, Penela, Petronila, Sarnago, Susana, Elorza, Ana, Jiménez-Sainz, M.Carmen, Mayor, Jr, Federico
Format: Article
Language:English
Subjects:
Animals
beta-Adrenergic Receptor Kinases
Cardiovascular
Chemokine receptor
Cyclic AMP-Dependent Protein Kinases - metabolism
Cyclic AMP-Dependent Protein Kinases - physiology
Desensitization
G protein-coupled receptor kinase
G-Protein-Coupled Receptor Kinase 3
GTP-Binding Proteins - metabolism
Humans
Mice
Receptors, Cell Surface - metabolism
Receptors, Cell Surface - physiology
Subcellular Fractions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)00495-5