Effects of long-term oral treatment with leflunomide on allergic sensitization, lymphocyte activation, and airway inflammation in a rat model of asthma

Background Short‐term treatment with leflunomide is effective in suppressing antigen‐specific antibody production and allergen‐induced bronchoconstriction after sensitization. This agent may thus have a role in future primary prevention strategies in allergic disease. Objective The current study aim...

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Bibliographic Details
Published in:Clinical and experimental allergy 1998-06, Vol.28 (6), p.758-764
Main Authors: UHLIG, T, COOPER, D, EBER, E, MCMENAMIN, C, WILDHABER, J. H, SLY, P. D
Format: Article
Language:English
Subjects:
acute-phase reaction
Administration, Inhalation
Administration, Oral
Age Factors
allergic sensitization
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Antibody Specificity - drug effects
Asthma - blood
Asthma - prevention & control
Biological and medical sciences
bronchoalveolar lavage fluid
Bronchoalveolar Lavage Fluid - cytology
Cell Division - drug effects
Disease Models, Animal
Histamine and antagonists. Allergy
Immunoglobulin E - blood
Immunoglobulin G - blood
immunoglobulins
immunomodulators
isoxazoles
Isoxazoles - administration & dosage
Isoxazoles - pharmacology
Leflunomide
Male
Medical sciences
Ovalbumin - immunology
Pharmacology. Drug treatments
Rats
Rats, Inbred BN
T-Lymphocytes - drug effects
Time Factors
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Summary:Background Short‐term treatment with leflunomide is effective in suppressing antigen‐specific antibody production and allergen‐induced bronchoconstriction after sensitization. This agent may thus have a role in future primary prevention strategies in allergic disease. Objective The current study aimed to determine whether long‐term oral treatment with leflunomide prevents allergic sensitization permanently. Methods After sensitization with ovalbumin, six groups of rats (n = 31) were treated daily with leflunomide or diluent for up to 30 days. Ovalbumin‐specific IgE and IgG were determined weekly for at least 2 weeks after cessation of treatment. T lymphocytes from another 21 animals were stimulated ex vivo with ovalbumin or concanavalin A. Results Ovalbumin‐specific IgE and IgG were lower during treatment with leflunomide compared with controls (P 
ISSN:0954-7894
1365-2222
DOI:10.1046/j.1365-2222.1998.00309.x