Histological and immunocytochemical studies of human psoriatic lesions transplanted onto SCID mice

To investigate the pathology of psoriasis, we developed an animal model for this disease using severe combined immunodeficiency (SCID) mice. These mice possess neither B nor T Lymphocytes so that both cellular and humoral immunities are impaired. For the in vivo study of psoriasis, human psoriatic s...

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Bibliographic Details
Published in:Journal of dermatological science 1998-06, Vol.17 (2), p.85-92
Main Authors: Sugai, Junichi, Iizuka, Mariko, Kawakubo, Yo, Ozawa, Akira, Ohkido, Muneo, Ueyama, Yoshihito, Tamaoki, Norikazu, Inokuchi, Sadaki, Shimamura, Kazuo
Format: Article
Language:English
Subjects:
Adult
AE 1
Animals
Disease Models, Animal
Female
Histocompatibility Antigens Class I - analysis
Humans
Immunohistochemistry
Male
Mice
Mice, SCID
Proliferating cell nuclear antigen (PCNA)
Proliferating Cell Nuclear Antigen - analysis
Psoriasis
Psoriasis - metabolism
Psoriasis - pathology
SCID mice
Skin Transplantation
Transplantation, Heterologous
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Summary:To investigate the pathology of psoriasis, we developed an animal model for this disease using severe combined immunodeficiency (SCID) mice. These mice possess neither B nor T Lymphocytes so that both cellular and humoral immunities are impaired. For the in vivo study of psoriasis, human psoriatic skin was grafted on SCID mice. Long-term morphological and immunohistochemical changes in the grafted skin ware examined for up to 22 weeks after transplantation. The human skin graft were generally well maintained during this period, but the histological and immunohistochemical findings characteristic of psoriasis, except for acanthosis and hyperkeratosis, gradually disappeared as lymphocytic infiltration of the psoriatic lesions declined.
ISSN:0923-1811
1873-569X
DOI:10.1016/S0923-1811(97)00077-7