SEQUENCE DETERMINATION OF ACTAGARDINE, A NOVEL LANTIBIOTIC, BY HOMONUCLEAR 2D NMR SPECTROSCOPY

By combination of several 1H NMR techniques, the sequence of actagardine has been elucidated. It has been shown that it is a tetracyclic 19-residue peptide antibiotic. It differs from the previously described lanthionine-containing peptide antibiotics belonging to the lantibiotic class.

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Bibliographic Details
Published in:Journal of antibiotics 1990/09/25, Vol.43(9), pp.1082-1088
Main Authors: KETTENRING, JÜRGEN K., MALABARBA, ADRIANO, VÉKEY, KÁROLY, CAVALLERI, BRUNO
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anti-Bacterial Agents - chemistry
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteriocins
Biological and medical sciences
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Molecular Sequence Data
Peptides - chemistry
Pharmacology. Drug treatments
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Description
Summary:By combination of several 1H NMR techniques, the sequence of actagardine has been elucidated. It has been shown that it is a tetracyclic 19-residue peptide antibiotic. It differs from the previously described lanthionine-containing peptide antibiotics belonging to the lantibiotic class.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.1082