Pathophysiological role of changing atrial size and pressure in modulation of atrial natriuretic factor during evolving experimental heart failure

• Published in: Cardiovascular research 1990-07, Vol.24 (7), p.570-577
• Main Authors: Moe, Gordon W, Angus, Carmella, Howard, Robert J, De Bold, Adolfo J, Armstrong, Paul W
• Format: Article
• Language: English
• Subjects: Animals; atrial natriuretic factor; Atrial Natriuretic Factor - blood; Biological and medical sciences; Cardiac Pacing, Artificial; Cardiology. Vascular system; Dogs; Heart Atria - pathology; Heart Failure - blood; Heart Failure - pathology; Heart Failure - physiopathology; left atrial dimension; left atrial pressure; Male; Medical sciences; Models, Cardiovascular; pacing induced heart failure; Pulmonary Wedge Pressure
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1093/cvr/24.7.570

Study objective – The aim was to study the interactions between pulmonary capillary wedge pressure (an estimate of left atrial pressure), left atrial dimension, and atrial natriuretic factor during evolving heart failure. Design – Sequential simultaneous measurements of haemodynamic variables, left atrial dimension, and plasma atrial natriuretic factor concentrations were obtained during evolving experimental pacing induced heart failure. Experimental material – Eight male mongrel dogs were paced (250 beats·min−1) to severe heart failure over 4.9(SD 1.8) weeks. Measurements and results – The development of heart failure was characterised by a progressive increase in pulmonary capillary wedge pressure and left atrial cross sectional area, from 5.6(1.3) mm Hg and 7.9(1.2) cm2 respectively at control, to 25.3(4.9) mm Hg and 14.2(2.5) cm2 respectively (both p