Adenosine receptors: new opportunities for future drugs

This review summarises current knowledge on adenosine receptors, an important G protein-coupled receptor. The four known adenosine receptor subtypes A 1, A 2A, A 2B, and A 3 are discussed with special reference to the opportunities for drug development.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 1998-06, Vol.6 (6), p.619-641
Main Authors: Poulsen, Sally-Ann, Quinn, Ronald J
Format: Article
Language:English
Subjects:
Adenosine
Adenosine - metabolism
Adenosine - physiology
Animals
GTP-Binding Proteins - metabolism
Humans
Ligands
Models, Molecular
molecular modelling
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
receptors
Receptors, Purinergic P1 - chemistry
Receptors, Purinergic P1 - drug effects
Receptors, Purinergic P1 - physiology
review
Structure-Activity Relationship
structure–activity
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Description
Summary:This review summarises current knowledge on adenosine receptors, an important G protein-coupled receptor. The four known adenosine receptor subtypes A 1, A 2A, A 2B, and A 3 are discussed with special reference to the opportunities for drug development.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(98)00038-8