Correlating structure and function in ATP-sensitive K + channels

ATP-sensitive K + channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The K ATP channel is an octameric complex of two unrelated types of subunit: a pore-forming s...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 1998-07, Vol.21 (7), p.288-294
Main Authors: Ashcroft, Frances M., Gribble, Fiona M.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
ATP-Binding Cassette Transporters
ATP-sensitive K+ channels
Biological and medical sciences
Cells - metabolism
Cellular biology
Diabetes Mellitus, Type 2 - genetics
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Genes, Regulator - genetics
Genetic Linkage
Hyperinsulinism - genetics
In Vitro Techniques
ion channel
Kir6.2
Models, Biological
Nervous system
Neurology
Nucleotides - metabolism
PHHI
Potassium Channels - metabolism
Potassium Channels - physiology
Potassium Channels, Inwardly Rectifying
Receptors, Drug - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Sulfonylurea Compounds - metabolism
Sulfonylurea Receptors
sulphonylurea receptor
Vertebrates: nervous system and sense organs
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Summary:ATP-sensitive K + channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The K ATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a regulatory subunit, the sulphonylurea receptor (SUR). This review focuses on the regulation of K ATP channel activity by nucleotides and cell metabolism and considers which regulatory mechanisms are intrinsic to Kir6.2 and which are conferred by association with SUR.
ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(98)01225-9