High-dose-rate intracavitary irradiation using linear source arrangement for stage II and III squamous cell carcinoma of the uterine cervix

• Published in: Radiotherapy and oncology 1998-05, Vol.47 (2), p.207-213
• Main Authors: Kagei, Kenji, Shirato, Hiroki, Nishioka, Takeshi, Kitahara, Toshihiro, Suzuki, Keishiro, Tomita, Masayoshi, Takamura, Akio, Arimoto, Takuro, Matsuoka, Syousuke, Mizoe, Jun-Etsu, Sakuragi, Noriaki, Fujimoto, Seiichiro, Miyasaka, Kazuo
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Brachytherapy; Carcinoma of the uterine cervix; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - radiotherapy; Dose Fractionation, Radiation; Female; High-dose-rate; Humans; Intracavitary irradiation; Linear source arrangement; Middle Aged; Radiotherapy Dosage; Survival Rate; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - radiotherapy
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/S0167-8140(97)00229-6

Purpose: The purpose of this article is to evaluate fractionated high-dose-rate (HDR) intracavitary irradiation using linear source arrangement (LSA) for patients with squamous cell carcinoma of the uterine cervix. Materials and methods: The subjects consisted of 217 patients (71 patients with stage II and 146 with stage III disease) who received external beam therapy (EBT) followed by fractionated HDR intracavitary irradiation using LSA between January 1980 and June 1990. In EBT, 40 Gy in 20 fractions (40 Gy/20 Fr) or 39.6 Gy/22 Fr was delivered to the whole pelvis and an additional 10 Gy/5 Fr or 10.8 Gy/6 Fr was delivered to the parametrium. The intracavitary irradiation dose was 30 Gy/6 Fr or 35 Gy/7 Fr with a daily fraction size of 5 Gy and two fractions per week. During the intracavitary treatment, most patients were treated on an out-patient basis. Results: Cause-specific 5-year survival rates were 77% for stage II and 50% for stage III. Pelvic failure rates were 13% for stage II and 36% for stage III. In multivariate analyses, improved cause-specific survival was significantly associated with stage II ( P=0.0003), higher pretreatment serum hemoglobin level ( P=0.0015), higher pretreatment serum total protein level ( P=0.0029), and shorter total treatment time ( P=0.0024). The rate of severe (grade 3 or 4) late complication was 2% for the rectum, 1% for the small intestine or sigmoid colon and 1% for the bladder. Conclusions: Fractionated HDR intracavitary irradiation using LSA is an effective treatment for patients with uterine cervical cancer without need for hospitalization.