Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors

The synthesis and evaluation of 1– 4 as potential inhibitors of GAR Tfase and AICAR Tfase are detailed.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 1998-06, Vol.6 (6), p.643-659
Main Authors: Boger, Dale L, Kochanny, Monica J, Cai, Hui, Wyatt, Diane, Kitos, Paul A, Warren, M.S, Ramcharan, J, Gooljarsingh, Lata T, Benkovic, Stephen J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Drug Design
Drug Screening Assays, Antitumor
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Hydroxymethyl and Formyl Transferases - antagonists & inhibitors
Mice
Phosphoribosylaminoimidazolecarboxamide Formyltransferase
Phosphoribosylglycinamide Formyltransferase
Pyrimidines - chemical synthesis
Pyrimidines - chemistry
Pyrimidines - pharmacology
Quinazolines - chemical synthesis
Quinazolines - chemistry
Quinazolines - pharmacology
Structure-Activity Relationship
Tumor Cells, Cultured
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Description
Summary:The synthesis and evaluation of 1– 4 as potential inhibitors of GAR Tfase and AICAR Tfase are detailed.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(98)00040-6