Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease

In nodular sclerosing Hodgkin's disease (NSHD), the prognostic relevance of the histopathological grading in two subtypes NSI (low-grade) and NSII (high-grade) remains controversial. Analysis of follicular dendritic cells (FDC) may provide new prognostic parameters. Tumours from 59 patients wit...

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Bibliographic Details
Published in:Histopathology 1998-06, Vol.32 (6), p.512-520
Main Authors: BAUR, A. S, MEUGE-MORAW, C, MICHEL, G, DELACRETAZ, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
Dendritic Cells - chemistry
Dendritic Cells - pathology
Female
Hematologic and hematopoietic diseases
Hodgkin Disease - diagnosis
Hodgkin Disease - mortality
Hodgkin Disease - pathology
Humans
Immunohistochemistry
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymph Nodes - chemistry
Lymph Nodes - pathology
Male
Medical sciences
Middle Aged
Multivariate Analysis
Prognosis
Reed-Sternberg Cells - pathology
Retrospective Studies
Survival Rate
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Summary:In nodular sclerosing Hodgkin's disease (NSHD), the prognostic relevance of the histopathological grading in two subtypes NSI (low-grade) and NSII (high-grade) remains controversial. Analysis of follicular dendritic cells (FDC) may provide new prognostic parameters. Tumours from 59 patients with NSHD were studied. Mean follow-up time was 8 years. Forty-one cases were classified as NSI and 18 as NSII. FDC were immunostained with the paraffin-resistant monoclonal antibodies CD21 and CNA.42. We distinguished three patterns in the neoplastic tissue: FDC1, the presence of well-defined follicle-like structures (n = 20); FDC2, the presence of largely destroyed FDC networks (n = 25); and FDC3, no or a few isolated FDC (n = 14). The three groups differed clearly regarding the frequency of relapse and the survival. The longest survival was seen in the FDC1 group, the shortest in the FDC3 group, the FDC2 group being intermediate (P = 0.0025). FDC status was a discriminating prognostic factor for all patients, and within various age and stage categories. Combining the FDC status and the NSI-NSII grading defined the best survival group as FDC1-NSI. Assessment of FDC pattern, associated with histological subtyping, brings valuable data for predicting survival and outcome in NSHD.
ISSN:0309-0167
1365-2559
DOI:10.1046/j.1365-2559.1998.t01-1-00418.x