HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES HYGROSCOPICUS: I. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL ACTIVITY

Strain C39108-P210-51 (ATCC 53653), an actinomycete isolated from a soil sample collected in India, was found to produce a new antitumor antibiotic, designated himastatin. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Streptomy...

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Bibliographic Details
Published in:Journal of antibiotics 1990/08/25, Vol.43(8), pp.956-960
Main Authors: LAM, KIN SING, HESLER, GRACE A., MATTEI, JACQUELINE M., MAMBER, STEPHEN W., FORENZA, SALVATORE, TOMITA, KOJI
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antineoplastic agents
Biological and medical sciences
Fermentation
General aspects
Gram-Positive Bacteria - drug effects
Leukemia P388 - drug therapy
Medical sciences
Melanoma, Experimental - drug therapy
Mice
Peptides, Cyclic - biosynthesis
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Peptides, Cyclic - therapeutic use
Pharmacology. Drug treatments
Soil Microbiology
Streptomyces - classification
Streptomyces - metabolism
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Summary:Strain C39108-P210-51 (ATCC 53653), an actinomycete isolated from a soil sample collected in India, was found to produce a new antitumor antibiotic, designated himastatin. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Streptomyces hygroscopicus C39108-P210-51. Himastatin shows antimicrobial activity against Gram-positive bacteria but it is inactive against Gram-negative bacteria. Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.956