Benzodiazepines alter cochleo-cochlear loop in humans

By using otoacoustic emission, we looked for change in outer hair cell (OHC) motile activity and medial olivocochlear (MOC) system inhibition due to benzodiazepine administration, a drug that is known to produce a pharmacological effect by interacting with GABAergic inhibitory neurotransmission. No...

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Bibliographic Details
Published in:Hearing research 1998-07, Vol.121 (1), p.71-76
Main Authors: Morand, N., Veuillet, E., Gagnieu, M.C., Lemoine, P., Collet, L.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Anti-Anxiety Agents - administration & dosage
Anti-Anxiety Agents - blood
Anti-Anxiety Agents - pharmacology
Biological and medical sciences
Cell Movement - drug effects
Cross-Over Studies
Double-Blind Method
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Fundamental and applied biological sciences. Psychology
Gamma-aminobutyric acid
gamma-Aminobutyric Acid - metabolism
Hair Cells, Auditory, Outer - drug effects
Humans
Male
Nerve Fibers - drug effects
Olivary Nucleus - anatomy & histology
Olivary Nucleus - drug effects
Olivocochlear efferent system
Otoacoustic emission
Otoacoustic Emissions, Spontaneous - drug effects
Outer hair cell
Oxazepam - administration & dosage
Oxazepam - blood
Oxazepam - pharmacology
Synaptic Transmission - drug effects
Vertebrates: nervous system and sense organs
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Summary:By using otoacoustic emission, we looked for change in outer hair cell (OHC) motile activity and medial olivocochlear (MOC) system inhibition due to benzodiazepine administration, a drug that is known to produce a pharmacological effect by interacting with GABAergic inhibitory neurotransmission. No effect was observed on OHC motile activity, in contrast benzodiazepines decreased MOC system effectiveness suggesting the existence of GABAergic fibers projecting onto the MOC system.
ISSN:0378-5955
1878-5891
DOI:10.1016/S0378-5955(98)00068-9