Transduction of imipenem resistance by wild-type bacteriophages carried by three strains of Pseudomonas aeruginosa isolated from a single source

Carbapenem resistance amongst clinical isolates of Pseudomonas aeruginosa is being reported with increasing frequency; for example, Krcmery & Trupl recently described an outbreak of infection caused by imipenem-resistant strains amongst patients at the National Institute of Oncology (NIO) in Bra...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1998-06, Vol.41 (6), p.660-662
Main Authors: Blahová, J, Králiková, K, Krcméry, V, Mlynarcík, D, Trupl, J
Format: Article
Language:English
Subjects:
Bacteriophages
beta-Lactam Resistance
Imipenem - pharmacology
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - virology
Thienamycins - pharmacology
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Summary:Carbapenem resistance amongst clinical isolates of Pseudomonas aeruginosa is being reported with increasing frequency; for example, Krcmery & Trupl recently described an outbreak of infection caused by imipenem-resistant strains amongst patients at the National Institute of Oncology (NIO) in Bratislava. Wild-type bacteriophages carried by lysogenic multidrug-resistant hospital strains of P. aeruginosa have been shown to transduce determinants of resistance to aminoglycosides and to beta -lactam antibiotics to susceptible recipient strains of this bacterium. Similarly, the generalized transducing phage, F-116, transduces genetic determinants of antibiotic resistance from resistant P. aeruginosa strains to susceptible recipient strains. We describe here the transduction of the determinants of resistance to antibiotics, including imipenem, by three wild-type bacteriophages carried by three multidrug-resistant strains of P. aeruginosa isolated from a single source.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/41.6.660