Increase of endothelin‐1 concentration in aqueous humour induced by argon laser trabeculoplasty in the rabbit. A preliminary study

• Published in: Acta ophthalmologica Scandinavica 1998-06, Vol.76 (3), p.289-293
• Main Authors: Holló, Gábor, Lakatos, Péter
• Format: Article
• Language: English
• Subjects: Animals; Anterior Chamber - surgery; Aqueous Humor - metabolism; Endothelin-1 - metabolism; Intraocular Pressure; Laser Therapy; Rabbits; Time Factors; Tonometry, Ocular; Trabeculectomy - methods
• ISSN: 1395-3907; 1600-0420
• DOI: 10.1034/j.1600-0420.1998.760307.x

To investigate the impact of argon laser trabeculoplasty (ALT) on endothelin-1 (ET-1) concentration of aqueous humour and intraocular pressure (IOP) in the rabbit. Standard ALT was performed on one eye of 19 pigmented rabbits. A modified treatment in which the laser light was focused on the inner limbal surface (argon laser scleroplasty, ALS) was also performed on one eye of a further 15 rabbits. IOP was measured with a Tono-Pen-2 tonometer before treatment, under general anaesthesia. Post-laser IOP measurements followed by aqueous humour aspiration were performed under general anaesthesia 4, 24 and 120 hours after treatment. IOP readings were considered relative values, since the tonometer was calibrated to the human eye and not to the rabbit eyeball. Different groups of animals were used for the tests after each time period. The groups of 4 hours time consisted of 9 animals which had undergone ALT and 5 which had undergone ALS. All the other groups consisted of 5 animals each. In the ALT group IOP decreased following treatment, and the IOP change (a relative change) showed a significant difference between the treated and the control eyes at all three follow-up times (paired t-test, p