Pulmonary Wegener's granulomatosis: changes at follow-up CT

The objective of this study was to assess the reversibility of pulmonary lesions in Wegener's granulomatosis using serial CT. We reviewed the follow-up CT scans of ten treated patients with confirmed Wegener's granulomatosis. The delay between the first evaluation before treatment and the...

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Bibliographic Details
Published in:European radiology 1998-01, Vol.8 (6), p.1009-1113
Main Authors: Attali, P, Begum, R, Ban Romdhane, H, Valeyre, D, Guillevin, L, Brauner, M W
Format: Article
Language:English
Subjects:
Aged
Female
Follow-Up Studies
Granulomatosis with Polyangiitis - diagnostic imaging
Humans
Lung - diagnostic imaging
Lung Diseases - diagnostic imaging
Male
Middle Aged
Nursing
Tomography, X-Ray Computed
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Summary:The objective of this study was to assess the reversibility of pulmonary lesions in Wegener's granulomatosis using serial CT. We reviewed the follow-up CT scans of ten treated patients with confirmed Wegener's granulomatosis. The delay between the first evaluation before treatment and the second, on patients in clinical and biological remission, ranged from 6 to 54 months (mean 20.5 months). Follow-up CT showed a decrease in the extent of disease in all cases. Lesions disappeared completely, without scarring, in 4 of 4 ground-glass opacities, 25 of 36 nodules, and 4 of 9 pulmonary consolidations; they disappeared with residual scarring in 8 of 8 masses, 3 of 9 pulmonary consolidations, and 2 of 36 nodules. The majority of lesions disappear without scarring. Residual fibrosis may follow the occurence of masses and pulmonary consolidation. Computed tomography permits assessment of cicatricial lesions.
ISSN:0938-7994
1432-1084
DOI:10.1007/s003300050506