A Viral Mechanism for Inhibition of the Cellular Phosphatase Calcineurin

The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosupp...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1998-07, Vol.281 (5376), p.562-565
Main Authors: Miskin, James E., Abrams, Charles C., Goatley, Lynnette C., Dixon, Linda K.
Format: Article
Language:English
Subjects:
African Swine Fever Virus - physiology
Amino Acid Sequence
Amino acids
Animals
Binding Sites
Biological and medical sciences
Calcineurin - metabolism
Calcineurin Inhibitors
Cell extracts
Cell Nucleus - metabolism
Cells, Cultured
Cellular biology
Cercopithecus aethiops
Coding
Cyclosporine - pharmacology
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Fundamental and applied biological sciences. Psychology
Genes
Genes, Reporter
Genetic regulation
Genetic transcription
Hogs
Immunology
Inhibition
Libraries
Macrophages, Alveolar - virology
Microbiology
Molecular Sequence Data
NF-kappa B - metabolism
NFATC Transcription Factors
Nuclear Proteins
Nucleotide sequences
Open reading frames
Phosphatases
Physiological aspects
Proteins
Recombinant Proteins - metabolism
Regulation
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Reporter genes
Reproduction
Swine
T lymphocytes
Transcription (Genetics)
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
Vero Cells
Viral Proteins - genetics
Viral Proteins - metabolism
Virology
Viruses
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Description
Summary:The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.281.5376.562