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Intranasal Administration of Denatured Type II Collagen and Its Fragments Can Delay the Onset of Collagen-Induced Arthritis
Collagen-induced arthritis (CIA) is an autoimmune animal model for some types of human rheumatoid arthritis (RA). We have evaluated the effectiveness of intranasal administration of antigen in inhibiting CIA in DBA/1 mice. The intranasal administration of heat-denatured or trypsin-digested bovine ty...
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| Published in: | Clinical immunology and immunopathology 1998-07, Vol.88 (1), p.70-79 |
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| container_title | Clinical immunology and immunopathology |
| container_volume | 88 |
| creator | Matsumoto, Takashi Ametani, Akio Hachimura, Satoshi Iwaya, Amane Taguchi, Yasuki Fujita, Kohtaro Shigehisa, Tamotsu Kaminogawa, Shuichi |
| description | Collagen-induced arthritis (CIA) is an autoimmune animal model for some types of human rheumatoid arthritis (RA). We have evaluated the effectiveness of intranasal administration of antigen in inhibiting CIA in DBA/1 mice. The intranasal administration of heat-denatured or trypsin-digested bovine type II collagen (CII) before immunization with CII strongly delayed the onset of CIA, whereas administration of native CII did not do so. The mice administered denatured or digested CII possessed much lower titers of anti-CII IgG2a than the control mice, whereas titers of anti-CII IgG1 and IgG2b were unchanged or slightly decreased. Responding to CII and peptides containing immunodominant T cell determinants, lymph node cells from mice administered denatured CII produced less IFN-γ. These results suggest that intranasal administration of antigen downregulated preferentially Th1-type responses, whereas an enhanced Th2-type response was not observed. We demonstrate that the methods shown here are a possible treatment for rheumatoid arthritis. |
| doi_str_mv | 10.1006/clin.1998.4521 |
| format | article |
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We have evaluated the effectiveness of intranasal administration of antigen in inhibiting CIA in DBA/1 mice. The intranasal administration of heat-denatured or trypsin-digested bovine type II collagen (CII) before immunization with CII strongly delayed the onset of CIA, whereas administration of native CII did not do so. The mice administered denatured or digested CII possessed much lower titers of anti-CII IgG2a than the control mice, whereas titers of anti-CII IgG1 and IgG2b were unchanged or slightly decreased. Responding to CII and peptides containing immunodominant T cell determinants, lymph node cells from mice administered denatured CII produced less IFN-γ. These results suggest that intranasal administration of antigen downregulated preferentially Th1-type responses, whereas an enhanced Th2-type response was not observed. We demonstrate that the methods shown here are a possible treatment for rheumatoid arthritis.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1006/clin.1998.4521</identifier><identifier>PMID: 9683552</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Administration, Intranasal ; AIDS/HIV ; Amino Acid Sequence ; Animals ; Arthritis - etiology ; Arthritis - immunology ; Arthritis - prevention & control ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - therapy ; Autoantibodies - blood ; Autoimmune Diseases - etiology ; Autoimmune Diseases - immunology ; Autoimmune Diseases - prevention & control ; Biological and medical sciences ; Cattle ; Collagen - administration & dosage ; Collagen - chemistry ; Collagen - immunology ; collagen-induced arthritis ; Disease Models, Animal ; Female ; Humans ; Immunodominant Epitopes - genetics ; Immunomodulators ; Interferon-gamma - biosynthesis ; Interferon-gamma - metabolism ; intranasal administration ; Medical sciences ; Mice ; Mice, Inbred DBA ; Molecular Sequence Data ; Peptide Fragments - administration & dosage ; Peptide Fragments - chemistry ; Peptide Fragments - immunology ; Pharmacology. Drug treatments ; Protein Denaturation ; Th1 Cells - immunology ; Th2 Cells - immunology ; type II collagen</subject><ispartof>Clinical immunology and immunopathology, 1998-07, Vol.88 (1), p.70-79</ispartof><rights>1998 Academic Press</rights><rights>1998 INIST-CNRS</rights><rights>Copyright 1998 Academic Press.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-5455762a3181cf738d8578cb703b7e2b31fbc6faee14764312c3e1dae2fb969d3</citedby><cites>FETCH-LOGICAL-c465t-5455762a3181cf738d8578cb703b7e2b31fbc6faee14764312c3e1dae2fb969d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2359109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9683552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Takashi</creatorcontrib><creatorcontrib>Ametani, Akio</creatorcontrib><creatorcontrib>Hachimura, Satoshi</creatorcontrib><creatorcontrib>Iwaya, Amane</creatorcontrib><creatorcontrib>Taguchi, Yasuki</creatorcontrib><creatorcontrib>Fujita, Kohtaro</creatorcontrib><creatorcontrib>Shigehisa, Tamotsu</creatorcontrib><creatorcontrib>Kaminogawa, Shuichi</creatorcontrib><title>Intranasal Administration of Denatured Type II Collagen and Its Fragments Can Delay the Onset of Collagen-Induced Arthritis</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Collagen-induced arthritis (CIA) is an autoimmune animal model for some types of human rheumatoid arthritis (RA). We have evaluated the effectiveness of intranasal administration of antigen in inhibiting CIA in DBA/1 mice. The intranasal administration of heat-denatured or trypsin-digested bovine type II collagen (CII) before immunization with CII strongly delayed the onset of CIA, whereas administration of native CII did not do so. The mice administered denatured or digested CII possessed much lower titers of anti-CII IgG2a than the control mice, whereas titers of anti-CII IgG1 and IgG2b were unchanged or slightly decreased. Responding to CII and peptides containing immunodominant T cell determinants, lymph node cells from mice administered denatured CII produced less IFN-γ. These results suggest that intranasal administration of antigen downregulated preferentially Th1-type responses, whereas an enhanced Th2-type response was not observed. We demonstrate that the methods shown here are a possible treatment for rheumatoid arthritis.</description><subject>Administration, Intranasal</subject><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Arthritis - etiology</subject><subject>Arthritis - immunology</subject><subject>Arthritis - prevention & control</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - therapy</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune Diseases - etiology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Collagen - administration & dosage</subject><subject>Collagen - chemistry</subject><subject>Collagen - immunology</subject><subject>collagen-induced arthritis</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Humans</subject><subject>Immunodominant Epitopes - genetics</subject><subject>Immunomodulators</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - metabolism</subject><subject>intranasal administration</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Molecular Sequence Data</subject><subject>Peptide Fragments - administration & dosage</subject><subject>Peptide Fragments - chemistry</subject><subject>Peptide Fragments - immunology</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Denaturation</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>type II collagen</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkU1r3DAQhkVpSLdJrr0VdCi9eatP2zoum6Y1BHJJzkKWxomKLW8lubD0z1dmt7mVnjRinncY5kHoAyVbSkj9xY4-bKlS7VZIRt-gDSWKVIwL-hZtyFpTxtQ79D6lH6QEBGku0aWqWy4l26DfXcjRBJPMiHdu8sGn8s9-Dnge8C0Ek5cIDj8eD4C7Du_ncTTPELAJDnc54btonicIpdqbUAKjOeL8AvghJMjrjL-JqgtusWXULuaX6LNP1-hiMGOCm_N7hZ7uvj7uv1f3D9-6_e6-sqKWuZJCyqZmhtOW2qHhrWtl09q-IbxvgPWcDr2tBwNARVMLTpnlQJ0BNvSqVo5foc-nuYc4_1wgZT35ZKGsFWBekm4JEVQw9l-Q1pI0SogCbk-gjXNKEQZ9iH4y8agp0asWvWrRqxa9aimBj-fJSz-Be8XPHkr_07lvkjXjUJRYn14xxqUqXgvWnjAo5_rlIepkPYRyVR_BZu1m_68N_gDHe6je</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Matsumoto, Takashi</creator><creator>Ametani, Akio</creator><creator>Hachimura, Satoshi</creator><creator>Iwaya, Amane</creator><creator>Taguchi, Yasuki</creator><creator>Fujita, Kohtaro</creator><creator>Shigehisa, Tamotsu</creator><creator>Kaminogawa, Shuichi</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Intranasal Administration of Denatured Type II Collagen and Its Fragments Can Delay the Onset of Collagen-Induced Arthritis</title><author>Matsumoto, Takashi ; Ametani, Akio ; Hachimura, Satoshi ; Iwaya, Amane ; Taguchi, Yasuki ; Fujita, Kohtaro ; Shigehisa, Tamotsu ; Kaminogawa, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-5455762a3181cf738d8578cb703b7e2b31fbc6faee14764312c3e1dae2fb969d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Intranasal</topic><topic>AIDS/HIV</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Arthritis - etiology</topic><topic>Arthritis - immunology</topic><topic>Arthritis - prevention & control</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Arthritis, Rheumatoid - therapy</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune Diseases - etiology</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Collagen - administration & dosage</topic><topic>Collagen - chemistry</topic><topic>Collagen - immunology</topic><topic>collagen-induced arthritis</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Humans</topic><topic>Immunodominant Epitopes - genetics</topic><topic>Immunomodulators</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - metabolism</topic><topic>intranasal administration</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>Molecular Sequence Data</topic><topic>Peptide Fragments - administration & dosage</topic><topic>Peptide Fragments - chemistry</topic><topic>Peptide Fragments - immunology</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Denaturation</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>type II collagen</topic><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Takashi</creatorcontrib><creatorcontrib>Ametani, Akio</creatorcontrib><creatorcontrib>Hachimura, Satoshi</creatorcontrib><creatorcontrib>Iwaya, Amane</creatorcontrib><creatorcontrib>Taguchi, Yasuki</creatorcontrib><creatorcontrib>Fujita, Kohtaro</creatorcontrib><creatorcontrib>Shigehisa, Tamotsu</creatorcontrib><creatorcontrib>Kaminogawa, Shuichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Takashi</au><au>Ametani, Akio</au><au>Hachimura, Satoshi</au><au>Iwaya, Amane</au><au>Taguchi, Yasuki</au><au>Fujita, Kohtaro</au><au>Shigehisa, Tamotsu</au><au>Kaminogawa, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intranasal Administration of Denatured Type II Collagen and Its Fragments Can Delay the Onset of Collagen-Induced Arthritis</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>88</volume><issue>1</issue><spage>70</spage><epage>79</epage><pages>70-79</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>Collagen-induced arthritis (CIA) is an autoimmune animal model for some types of human rheumatoid arthritis (RA). We have evaluated the effectiveness of intranasal administration of antigen in inhibiting CIA in DBA/1 mice. The intranasal administration of heat-denatured or trypsin-digested bovine type II collagen (CII) before immunization with CII strongly delayed the onset of CIA, whereas administration of native CII did not do so. The mice administered denatured or digested CII possessed much lower titers of anti-CII IgG2a than the control mice, whereas titers of anti-CII IgG1 and IgG2b were unchanged or slightly decreased. Responding to CII and peptides containing immunodominant T cell determinants, lymph node cells from mice administered denatured CII produced less IFN-γ. These results suggest that intranasal administration of antigen downregulated preferentially Th1-type responses, whereas an enhanced Th2-type response was not observed. We demonstrate that the methods shown here are a possible treatment for rheumatoid arthritis.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>9683552</pmid><doi>10.1006/clin.1998.4521</doi><tpages>10</tpages></addata></record> |
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| ispartof | Clinical immunology and immunopathology, 1998-07, Vol.88 (1), p.70-79 |
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| subjects | Administration, Intranasal AIDS/HIV Amino Acid Sequence Animals Arthritis - etiology Arthritis - immunology Arthritis - prevention & control Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy Autoantibodies - blood Autoimmune Diseases - etiology Autoimmune Diseases - immunology Autoimmune Diseases - prevention & control Biological and medical sciences Cattle Collagen - administration & dosage Collagen - chemistry Collagen - immunology collagen-induced arthritis Disease Models, Animal Female Humans Immunodominant Epitopes - genetics Immunomodulators Interferon-gamma - biosynthesis Interferon-gamma - metabolism intranasal administration Medical sciences Mice Mice, Inbred DBA Molecular Sequence Data Peptide Fragments - administration & dosage Peptide Fragments - chemistry Peptide Fragments - immunology Pharmacology. Drug treatments Protein Denaturation Th1 Cells - immunology Th2 Cells - immunology type II collagen |
| title | Intranasal Administration of Denatured Type II Collagen and Its Fragments Can Delay the Onset of Collagen-Induced Arthritis |
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