Simplifying ovulation induction for surrogacy in women with Mayer-Rokitansky-Kuster-Hauser syndrome

A simple approach for ovulation induction in women with Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH-S) during in-vitro fertilization (IVF)/freezing/surrogacy cycles was evaluated. Weekly progesterone plasma concentrations were measured in order to accurately establish the luteal phase in MRKH-S wo...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1998-06, Vol.13 (6), p.1470-1471
Main Authors: Ben-Rafael, Z, Bar-Hava, I, Levy, T, Orvieto, R
Format: Article
Language:English
Subjects:
Amenorrhea - blood
Biological and medical sciences
Birth control
Female
Fertilization in Vitro
Gonadotropin-Releasing Hormone - administration & dosage
Gonadotropin-Releasing Hormone - analogs & derivatives
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Menotropins - administration & dosage
Ovulation Induction - methods
Pregnancy
Progesterone - blood
Sterility. Assisted procreation
Syndrome
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Summary:A simple approach for ovulation induction in women with Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH-S) during in-vitro fertilization (IVF)/freezing/surrogacy cycles was evaluated. Weekly progesterone plasma concentrations were measured in order to accurately establish the luteal phase in MRKH-S women. When a rising titre was detected, a gonadotrophin-releasing hormone analogue (GnRHa) was administered as part of a long protocol. Two weeks later human menopausal gonadotrophin (HMG) therapy was started. Ten treatment cycles in four women with MRKH-S were carried out. In all cases, three or less progesterone estimations were needed. Three of the four women are now, through surrogacy, genetic mothers; one of them has two children. We concluded that weekly determination of progesterone plasma concentration is a convenient, efficient and inexpensive simple approach to identify the luteal phase, and therefore suitable to the start of a GnRHa/HMG protocol in MRKH-S women enrolled in an assisted reproduction technology programme.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/13.6.1470